ArticleMolecular biology of the cell2006
TIP-1 has PDZ scaffold antagonist activity.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023Article
- Article
- Role and mechanisms of regulation of the basolateral KActa physiologica (Oxford, England) · 2017Review
- A sequence upstream of canonical PDZ-binding motif within CFTR COOH-terminus enhances NHERF1 interaction.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins.Biology · 2015Review
- Article
- Regulation of potassium channel trafficking in the distal nephron.Current opinion in nephrology and hypertension · 2013Review
- New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).Biochemical and biophysical research communications · 2013Article
- Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.The Journal of biological chemistry · 2013Article
- High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice.Cancer letters · 2013Article
- Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif.Biochemistry · 2012Article
- Plasticity of PDZ domains in ligand recognition and signaling.FEBS letters · 2012Review
- The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.Biochemical and biophysical research communications · 2012Article
- Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions.The Journal of clinical investigation · 2012Article
- Article
- Functional implications of structural predictions for alternative splice proteins expressed in Her2/neu-induced breast cancers.Journal of proteome research · 2011Article
- Promiscuous binding at the crossroads of numerous cancer pathways: insight from the binding of glutaminase interacting protein with glutaminase L.Biochemistry · 2011Article
- The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.British journal of cancer · 2011Article
- TIP-1 translocation onto the cell plasma membrane is a molecular biomarker of tumor response to ionizing radiation.PloS one · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
PDZ proteins usually contain multiple protein-protein interaction domains and act as molecular scaffolds that are important for the generation and maintenance of cell polarity and cell signaling. Here, we identify and characterize TIP-1 as an atypical PDZ protein that is composed almost entirely of a single PDZ domain and functions as a negative regulator of PDZ-based scaffolding. We found that TIP-1 competes with the basolateral membrane mLin-7/CASK complex for interaction with the potassium channel Kir 2.3 in model renal epithelia. Consequently, polarized plasma membrane expression of Kir 2.3 is disrupted resulting in pronounced endosomal targeting of the channel, similar to the phenotype observed for mutant Kir 2.3 channels lacking the PDZ-binding motif. TIP-1 is ubiquitously expressed, raising the possibility that TIP-1 may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.