ArticleMolecular biology of the cell2006
Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Inorganic Polyphosphate Modulates Chromosome Transmission Fidelity in the Fission YeastBiomolecules · 2025Article
- Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry inJournal of fungi (Basel, Switzerland) · 2022Article
- Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex inG3 (Bethesda, Md.) · 2019Article
- Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK inGenetics · 2019Article
- Article
- Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins.Molecular and cellular biology · 2012Article
- RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.EMBO reports · 2012Article
- KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.Molecular biology of the cell · 2008Article
- The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity.The EMBO journal · 2007Article
- The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.Molecular biology of the cell · 2007Article
- Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4.PLoS genetics · 2007Article
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8 authors.
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Abstract
The fission yeast multiprotein-component Sim4 complex plays a fundamental role in the assembly of a functional kinetochore. It affects centromere association of the histone H3 variant CENP-A as well as kinetochore association of the DASH complex. Here, multicopy suppressor analysis of a mutant version of the Sim4 complex component Mal2 identified the essential Fta2 kinetochore protein, which is required for bipolar chromosome attachment. Kinetochore localization of Mal2 and Fta2 depends on each other, and overexpression of one protein can rescue the phenotype of the mutant version of the other protein. fta2 mal2 double mutants were inviable, implying that the two proteins have an overlapping function. This close interaction with Fta2 is not shared by other Sim4 complex components, indicating the existence of functional subgroups within this complex. The Sim4 complex seems to be assembled in a hierarchical way, because Fta2 is localized correctly in a sim4 mutant. However, Fta2 kinetochore localization is reduced in a spc7 mutant. Spc7, a suppressor of the EB1 family member Mal3, is part of the conserved Ndc80-MIND-Spc7 kinetochore complex.
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