ArticleExperimental brain research2007
Prostaglandin E2 potentiates the excitability of small diameter trigeminal root ganglion neurons projecting onto the superficial layer of the cervical dorsal horn in rats.
Article in Experimental brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Pathophysiology of Post-Traumatic Trigeminal Neuropathic Pain.Biomolecules · 2022Review
- Chronic defects in intraspinal mechanisms of spike encoding by spinal motoneurons following chemotherapy.Experimental neurology · 2020Article
- Effects of alkaloids on peripheral neuropathic pain: a review.Chinese medicine · 2020Review
- Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling.Journal of inflammation (London, England) · 2018Article
- Modulatory Mechanism of Nociceptive Neuronal Activity by Dietary Constituent Resveratrol.International journal of molecular sciences · 2016Review
- Resveratrol attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats.Molecular pain · 2016Article
- Primary culture of trigeminal satellite glial cells: a cell-based platform to study morphology and function of peripheral glia.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Modulation of TTX-sensitive voltage-dependent Na+ channels by β-bungarotoxin in rat cerebellar neurons.BMC neuroscience · 2012Article
- Alteration of primary afferent activity following inferior alveolar nerve transection in rats.Molecular pain · 2010Article
- Pulsed radiofrequency treatment for the management of trigeminal neuropathic pain following tooth extraction: A case report.Saudi journal of anaesthesiaArticle
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3 authors at 1 institution in 1 country.
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Abstract
The aim of the present study was to investigate how prostaglandin E2 (PGE2) affects the excitability of trigeminal root ganglion (TRG) neurons, projecting onto the superficial layer of the cervical dorsal horn, using fluorescence retrograde tracing and perforated patch-clamp techniques. TRG neurons were retrogradely labeled with fluorogold (FG). The cell diameter of FG-labeled neurons was small (< 30 microm). Under the voltage-clamp mode, application of PGE2 (0.01-10 microM) concentration-dependently increased the magnitude of the peak tetrodotoxin-resistant sodium current (TTX-R I(Na)) and this current was maximal at a concentration of 1 microM. One micromolar PGE2 application caused a hyperpolarizing shift of 8.3 mV in the activation curve for TTX-R I(Na). In the current-clamp mode, the PGE2 (1 microM) application significantly increased the number of action potentials during the depolarizing step pulses as well as the level of overshoot but had no significant effect on the resting membrane potential. These results suggest that the excitability of small diameter TRG neurons seen after 1 microM PGE2 application is involved in an increase in the
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