ReviewAnalytical and bioanalytical chemistry2006
Optical molecular imaging for systems biology: from molecule to organism.
Review in Analytical and bioanalytical chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.Transplantation · 2017Review
- Antibody-based imaging strategies for cancer.Cancer metastasis reviews · 2014Review
- New researches and application progress of commonly used optical molecular imaging technology.BioMed research international · 2014Review
- Light microscopy applications in systems biology: opportunities and challenges.Cell communication and signaling : CCS · 2013Article
- Multiscale imaging and computational modeling of blood flow in the tumor vasculature.Annals of biomedical engineering · 2012Review
- Selective targeting of microglia by quantum dots.Journal of neuroinflammation · 2012Article
- FLIM-FRET Imaging of Caspase-3 Activity in Live Cells Using Pair of Red Fluorescent Proteins.Theranostics · 2012Article
- NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening.Chemistry & biology · 2011Article
- Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength.Journal of the American Chemical Society · 2009Article
- Imaging the glycome.Proceedings of the National Academy of Sciences of the United States of America · 2009Review
- ULTRASHORT PULSE MULTISPECTRAL NONLINEAR OPTICAL MICROSCOPY.Journal of innovative optical health sciences · 2009Article
- Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging.Chemical communications (Cambridge, England) · 2008Article
- Bioinformatics in China: a personal perspective.PLoS computational biology · 2008Review
- Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells.Journal of molecular medicine (Berlin, Germany) · 2008Article
- A near-infrared optical tomography system based on photomultiplier tube.International journal of biomedical imaging · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of highly efficient analytical methods capable of probing biological systems at system level is an important task that is required in order to meet the requirements of the emerging field of systems biology. Optical molecular imaging (OMI) is a very powerful tool for studying the temporal and spatial dynamics of specific biomolecules and their interactions in real time in vivo. In this article, recent advances in OMI are reviewed extensively, such as the development of molecular probes that make imaging brighter, more stable and more informative (e.g., FPs and semiconductor nanocrystals, also referred to as quantum dots), the development of imaging approaches that provide higher resolution and greater tissue penetration, and applications for measuring biological events from molecule to organism level, including gene expression, protein and subcellular compartment localization, protein activation and interaction, and low-mass molecule dynamics. These advances are of great significance in the field of biological science and could also be applied to disease diagnosis and pharmaceutical screening. Further developments in OMI for systems biology are also proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.