ArticleBlood2007
Antiadhesive effect of fibrinogen: a safeguard for thrombus stability.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke.Annals of neurology · 2026Article
- Structural instability of the superficial layers of the fibrinogen matrix contributes to its nonadhesive properties.Acta biomaterialia · 2025Article
- Vascular leakage and angiogenesis in wound healing: a review.Molecular biology reports · 2025Review
- Emerging Elastic Micro-Nano Materials for Diagnosis and Treatment of Thrombosis.Research (Washington, D.C.) · 2025Review
- Modification of Extracellular Matrix by the Product of DHA Oxidation Switches Macrophage Adhesion Patterns and Promotes Retention of Macrophages During Chronic Inflammation.Frontiers in immunology · 2022Article
- Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis.International journal of molecular sciences · 2021Review
- Biomaterials to Prevent Post-Operative Adhesion.Materials (Basel, Switzerland) · 2020Review
- Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.Haematologica · 2019Article
- Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes.Biomaterials science · 2019Article
- Protein corona: a new approach for nanomedicine design.International journal of nanomedicine · 2017Review
- Deposition of fibrinogen on the surface of in vitro thrombi prevents platelet adhesion.Thrombosis research · 2015Article
- Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating.Biomaterials · 2015Article
- Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.Journal of biomedical materials research. Part A · 2015Article
- Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices.Ultramicroscopy · 2014Article
- The assembly of nonadhesive fibrinogen matrices depends on the αC regions of the fibrinogen molecule.The Journal of biological chemistry · 2012Article
- Fibrinogen counteracts the antiadhesive effect of fibrin-bound plasminogen by preventing its activation by adherent U937 monocytic cells.Journal of thrombosis and haemostasis : JTH · 2012Article
- Article
- Origin of the nonadhesive properties of fibrinogen matrices probed by force spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- Plasminogen on the surfaces of fibrin clots prevents adhesion of leukocytes and platelets.Journal of thrombosis and haemostasis : JTH · 2010Article
- Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates.Biochemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The recruitment of phagocytic leukocytes to sites of vessel wall injury plays an important role in thrombus dissolution by proteases elaborated on their adhesion. However, leukocyte adhesion to the fibrin clot can be detrimental at the early stages of wound healing when hemostatic plug integrity is critical for preventing blood loss. Adhesion of circulating leukocytes to the insoluble fibrin(ogen) matrix is mediated by integrins and occurs in the presence of a high concentration of plasma fibrinogen. In this study, the possibility that soluble fibrinogen could protect fibrin from excessive adhesion of leukocytes was examined. Fibrinogen was a potent inhibitor of adhesion of U937 monocytoid cells and neutrophils to fibrin gel and immobilized fibrin(ogen). An investigation of the mechanism by which soluble fibrinogen exerts its influence on leukocyte adhesion indicated that it did not block integrins but rather associated with the fibrin(ogen) substrate. Consequently, leukocytes that engage fibrinogen molecules loosely bound to the surface of fibrin(ogen) matrix are not able to consolidate their grip on the substrate; subsequently, cells detach. This conclusion is based on the evidence obtained in adhesion studies using various cells and performed under static and flow conditions. These findings reveal a new role of fibrinogen in integrin-mediated leukocyte adhesion and suggest that this mechanism may protect the thrombus from premature dissolution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.