ArticleJournal of immunology (Baltimore, Md. : 1950)2006
CXCR3 and IFN protein-10 in Pneumocystis pneumonia.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Immune Responses toJournal of inflammation research · 2026Review
- Dynamics of host immune responses and a potential function of Trem2Respiratory research · 2024Article
- Circulating and Pulmonary T-cell Populations Driving the Immune Response in Non-HIV Immunocompromised Patients withInternational journal of medical sciences · 2019Article
- Molecular Mechanisms of Mild and Severe Pneumonia: Insights from RNA Sequencing.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Methods of Controlling Invasive Fungal Infections Using CD8Frontiers in immunology · 2017Review
- Pediatric Acute Respiratory Distress Syndrome: Fibrosis versus Repair.Frontiers in pediatrics · 2016Review
- Characterization of chemokine and chemokine receptor expression during Pneumocystis infection in healthy and immunodeficient mice.Microbes and infection · 2015Article
- Vaccine immunity against fungal infections.Current opinion in immunology · 2014Review
- Acute respiratory distress syndrome: new definition, current and future therapeutic options.Journal of thoracic disease · 2013Article
- Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice.The Journal of clinical investigation · 2012Article
- Effect of different interferonα2 preparations on IP10 and ET-1 release from human lung cells.PloS one · 2012Article
- Gene therapy for ALI/ARDS.Critical care clinics · 2011Review
- γδ T cells attenuate bleomycin-induced fibrosis through the production of CXCL10.The American journal of pathology · 2011Article
- Current understanding of Pneumocystis immunology.Future microbiology · 2010Review
- Lymphocyte apoptosis in murine Pneumocystis pneumonia.Respiratory research · 2009Article
- PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.Blood · 2008Article
- Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice.Journal of leukocyte biology · 2008Article
- Interleukin-12 and host defense against murine Pneumocystis pneumonia.Infection and immunity · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We have previously shown that Tc1 CD8(+) T cells have in vitro and in vivo effector activity against Pneumocystis (PC) infection in mice. Because these cells have preferential expression of CXCR3, we investigated whether CXCR3 was required for host defense activity against PC. Mice deficient in CXCR3 but CD4(+) T cell intact, showed an initial delay but were able to clear the infectious challenge, indicating that CXCR3 signaling is not essential for clearance of PC. CD4-depleted mice had lower levels of monokine induced by IFN-gamma, IFN protein-10 (IP-10), and IFN-inducible T cell alpha-chemoattractant at day 7 of infection and are permissive to PC infection. Overexpression of IP-10 in the lungs by adenoviral gene transfer did not accelerate clearance of infection in control mice but accelerated clearance by day 28 in mice depleted of CD4(+) T cells. This effect was associated with increased recruitment of CD8(+) T to the lungs with higher CXCR3(+) expression levels and enhanced IFN-gamma secretion upon in vitro activation compared with control mice. These results indicate that the CXCR3 chemokines are part of the host defense response to PC, and that IP-10 can direct Tc1 CD8(+) T cell recruitment to the lungs and contribute to host defense against PC even in the absence of CD4(+) T cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.