ArticleJournal of the Royal Society, Interface2005
Adherence to antiretroviral therapy and its impact on clinical outcome in HIV-infected patients.
Article in Journal of the Royal Society, Interface, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Individual longitudinal compliance to neglected tropical disease mass drug administration programmes, a systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial.Antimicrobial agents and chemotherapy · 2013Trial
- Health outcomes and cost-effectiveness of treating depression in people with HIV in Sub-Saharan Africa: a model-based analysis.AIDS care · 2021Article
- Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia.PloS one · 2020Article
- Getting less of what you want: reductions in statistical power and increased bias when categorizing medication adherence data.Journal of behavioral medicine · 2016Article
- Psychiatric disorders and adherence to antiretroviral therapy among a population of HIV-infected adults in Nigeria.International journal of STD & AIDS · 2016Article
- Novel Approaches for Visualizing and Analyzing Dose-Timing Data from Electronic Drug Monitors, or "How the 'Broken Window' Theory Pertains to ART Adherence".AIDS and behavior · 2015Article
- Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models.Advanced drug delivery reviews · 2013Review
- Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV.Journal of the Royal Society, Interface · 2012Article
- Basic PK/PD principles of drug effects in circular/proliferative systems for disease modelling.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- Modelling imperfect adherence to HIV induction therapy.BMC infectious diseases · 2010Article
- Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility.Journal of theoretical biology · 2007Article
- Adherence to antiretroviral HIV drugs: how many doses can you miss before resistance emerges?Proceedings. Biological sciences · 2006Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyse data on patient adherence to prescribed regimens and surrogate markers of clinical outcome for 168 human immunodeficiency virus infected patients treated with antiretroviral therapy. Data on patient adherence consisted of dose-timing measurements collected for an average of 12 months per patient via electronic monitoring of bottle opening events. We first discuss how such data can be presented to highlight suboptimal adherence patterns and between-patient differences, before introducing two novel methods by which such data can be statistically modelled. Correlations between adherence and subsequent measures of viral load and CD4+T-cell counts are then evaluated. We show that summary measures of short-term adherence, which incorporate pharmacokinetic and pharmacodynamic data on the monitored regimen, predict suboptimal trends in viral load and CD4+T-cell counts better than measures based on adherence data alone.
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Registered trials
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