ArticleJournal of the Royal Society, Interface2005
On multiscale approaches to three-dimensional modelling of morphogenesis.
Article in Journal of the Royal Society, Interface, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.Nature communications · 2024Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Role of turgor-pressure induced boundary tension in the maintenance of the shoot apical meristem ofJournal of the Royal Society, Interface · 2023Article
- Biophysical models of early mammalian embryogenesis.Stem cell reports · 2023Review
- Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors.Scientific reports · 2022Article
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- How and why to build a mathematical model: A case study using prion aggregation.The Journal of biological chemistry · 2020Review
- Agent-based modeling of morphogenetic systems: Advantages and challenges.PLoS computational biology · 2019Review
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
- Polarization of concave domains by traveling wave pinning.PloS one · 2017Article
- Mechanical Regulation of Three-Dimensional Epithelial Fold Pattern Formation in the Mouse Oviduct.Biophysical journal · 2016Article
- Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation.Journal of the Royal Society, Interface · 2014Article
- A computational model predicting disruption of blood vessel development.PLoS computational biology · 2013Article
- Digit patterning during limb development as a result of the BMP-receptor interaction.Scientific reports · 2012Article
- Modeling cellular processes in 3D.Trends in cell biology · 2011Review
- Rule-based multi-level modeling of cell biological systems.BMC systems biology · 2011Article
- Computer simulation of cellular patterning within the Drosophila pupal eye.PLoS computational biology · 2010Article
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- Systems biology of embryogenesis.Reproduction, fertility, and development · 2010Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction-diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.