ArticleJournal of the Royal Society, Interface2005
Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility.
Article in Journal of the Royal Society, Interface, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Interventions to reduce the risk of surgically transmitted Creutzfeldt-Jakob disease: a cost-effective modelling review.Health technology assessment (Winchester, England) · 2020Pooled it
- Risk of variant Creutzfeldt-Jakob disease transmission by blood transfusion in Australia.Vox sanguinis · 2022Article
- Article
- All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD.PloS one · 2011Article
- Article
- B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.Journal of virology · 2010Article
- Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.PloS one · 2009Article
- Prevalence of disease related prion protein in anonymous tonsil specimens in Britain: cross sectional opportunistic survey.BMJ (Clinical research ed.) · 2009Article
- Prevalence of sheep infected with classical scrapie in Great Britain: integrating multiple sources of surveillance data for 2002.Journal of the Royal Society, Interface · 2008Article
- Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.BMC medical genetics · 2008Article
- Prominent and persistent extraneural infection in human PrP transgenic mice infected with variant CJD.PloS one · 2008Article
- Application of Atomic Dielectric Resonance Spectroscopy for the screening of blood samples from patients with clinical variant and sporadic CJD.Journal of translational medicine · 2007Article
- Is there the potential for an epidemic of variant Creutzfeldt-Jakob disease via blood transfusion in the UK?Journal of the Royal Society, Interface · 2007Article
- Blood transfusion and spread of variant Creutzfeldt-Jakob disease.Emerging infectious diseases · 2007Article
- Factors determining the potential for onward transmission of variant Creutzfeldt-Jakob disease via surgical instruments.Journal of the Royal Society, Interface · 2006Article
- Human prion disease and relative risk associated with chronic wasting disease.Emerging infectious diseases · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom appears to be in decline, with only four deaths reported this year (to 6 September 2004). However, results of a survey of lymphoreticular tissues have suggested a substantially higher prevalence of vCJD than expected from the clinical data alone. There are two plausible explanations for this discrepancy: first, a proportion of those infected will not develop clinical disease (subclinical infection); and second, the genetic group in which no clinical cases of vCJD have yet occurred is susceptible. Using mathematical models for the primary transmission of bovine spongiform encephalopathy to humans, we explore the impact of these hypotheses on case predictions. Under the first hypothesis, the results suggest relatively few future cases will arise via primary transmission, but that these cases are a small proportion of those infected, with most having subclinical infection. Under the second hypothesis, results suggest a maximum fivefold increase in cases, but this hypothesis is unable to account for the discrepancy between clinical cases and the estimated prevalence. Predictions of future cases of vCJD therefore remain uncertain, particularly given the recent identification of additional cases infected via blood transfusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.