ArticleJournal of biomedical science2006
Methamphetamine-induced behavioral sensitization in mice: alterations in mu-opioid receptor.
Article in Journal of biomedical science, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02330419 (Better Than Study), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among MSM
Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Feasibility, Acceptability, and Tolerability of Targeted Naltrexone for Nondependent Methamphetamine-Using and Binge-Drinking Men Who Have Sex with Men.Journal of acquired immune deficiency syndromes (1999) · 2016Trial
- The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022Review
- Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail.Frontiers in pharmacology · 2022Review
- Differential modulation of methamphetamine-mediated behavioral sensitization by overexpression of Mu opioid receptors in nucleus accumbens and ventral tegmental area.Psychopharmacology · 2016Article
- Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in the nucleus accumbens.Translational psychiatry · 2015Article
- Anxiety Assessment in Methamphetamine - Sensitized and Withdrawn Rats: Immediate and Delayed Effects.Iranian journal of psychiatry · 2015Article
- Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature.Drug and alcohol dependence · 2014Review
- Argon prevents the development of locomotor sensitization to amphetamine and amphetamine-induced changes in mu opioid receptor in the nucleus accumbens.Medical gas research · 2014Article
- Pharmacotherapy for stimulant-related disorders.Current psychiatry reports · 2013Review
- The effects of lobeline and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation.Metabolic brain disease · 2012Article
- Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice.Journal of biomedical science · 2011Article
- MOP Reduction During Long-Term Methamphetamine Withdrawal was Restored by Chronic Post-Treatment with Fluoxetine.Current neuropharmacology · 2011Article
- Involvement of µ-Opioid Receptor in Methamphetamine-Induced Behavioral Sensitization.Current neuropharmacology · 2011Article
- Methylphenidate potentiates morphine-induced antinociception, hyperthermia, and locomotor activity in young adult rats.Pharmacology, biochemistry, and behavior · 2009Article
- Endogenous opiates and behavior: 2006.Peptides · 2007Review
- Alleviation of Methamphetamine Sensitization by Partially Lesioning Dopaminergic Terminals with 6-Hydroxydopamine in Nucleus Accumbens.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We had previously demonstrated that opioid receptors contribute to the induction and expression of behavioral sensitization induced by repeated daily injection with 2.5 mg/kg of methamphetamine for 7 days. Using the same regimen, the present study investigated the alterations in mu-opioid receptor during the induction (on days 2, 5, and 8) and expression (on days 11 and 21) periods of behavioral sensitization. Radioligand binding revealed that the maximal binding of mu-opioid receptor was not changed on days 2 and 5, but down-regulated on day 8. After cessation of drug treatment, the maximal binding of mu-opioid receptor gradually and time-dependently returned to normal level on day 11 and up-regulated on day 21. In contrast, no changes in delta- and kappa-opioid receptors were detectable on any given day examined. The potency of DAMGO for [(35)S]-GTPgammaS coupling was enhanced on days 2, 5, 11, and 21. Moreover, 1 muM of naltrexone or beta-chlornaltrexamine significantly suppressed the basal [(35)S]-GTPgammaS coupling on days 2, 11, and 21. These findings indicate enhanced responsiveness and elevated constitutive activity of mu-opioid receptor. In summary, our data clearly demonstrate that alterations in mu-opioid receptor are involved in and may contribute to the sensitization to locomotor stimulating effect of methamphetamine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.