ArticlePflugers Archiv : European journal of physiology2006
Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.Signal transduction and targeted therapy · 2026Article
- Article
- Structural Basis for pH-gating of the KNature communications · 2022Article
- mGluR3 Activation Recruits Cytoplasmic TWIK-1 Channels to Membrane that Enhances Ammonium Uptake in Hippocampal Astrocytes.Molecular neurobiology · 2016Article
- Genetic Deletion of TREK-1 or TWIK-1/TREK-1 Potassium Channels does not Alter the Basic Electrophysiological Properties of Mature Hippocampal Astrocytes In Situ.Frontiers in cellular neuroscience · 2016Article
- New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Review
- The family of K2P channels: salient structural and functional properties.The Journal of physiology · 2015Review
- Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.Pflugers Archiv : European journal of physiology · 2015Review
- A Grhl2-dependent gene network controls trophoblast branching morphogenesis.Development (Cambridge, England) · 2015Article
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.Frontiers in cellular neuroscience · 2013Article
- TWIK1, a unique background channel with variable ion selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A Kir2.3-like K+ conductance in mouse cortical collecting duct principal cells.The Journal of membrane biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TWIK-1, a member of the two-pore domain K(+) channel family, is expressed in brain, kidney, and lung. The aim of this study was to examine the effect of loss of TWIK-1 on the renal cortical collecting duct. Ducts were isolated from wild-type and TWIK-1 knockout mice by enzyme digestion and whole-cell clamp obtained via the basolateral membrane. Current- and voltage-clamp approaches were used to examine K(+) conductances. No difference was observed between intercalated cells from wild-type or knockout ducts. In contrast, knockout principal cells were hyperpolarized compared to wild-type cells and had a reduced membrane conductance. This was a consequence of a fall in a barium-insensitive, quinidine-sensitive conductance (G (Quin)). G (Quin) demonstrated outward rectification and had a relatively low K(+) to Na(+) selectivity ratio. Loss of G (Quin) would be expected to lead to the hyperpolarization observed in knockout ducts by increasing fractional K(+) conductance and Na(+) uptake by the cell. Consistent with this hypothesis, knockout ducts had an increased diameter in comparison to wild-type ducts. These data suggest that G (Quin) contributes to the resting membrane potential in the cortical collecting duct and that a fall in G (Quin) could be an adaptive response in TWIK-1 knockout ducts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.