ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2007
Expression of CD18 on the neutrophils of patients with diabetic retinopathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Plasma and aqueous humor levels of Maresin-1 in patients with diabetic retinopathy.Scientific reports · 2026Article
- CD8+T Cell-Related Gene Biomarkers in Macular Edema of Diabetic Retinopathy.Frontiers in endocrinology · 2022Article
- Sequential and Dynamic Variations of IL-6, CD18, ICAM, TNF-Disease markers · 2022Article
- Review
- Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation.Mediators of inflammation · 2017Article
- Lymphoblastoid Cell Lines as a Tool to Study Inter-Individual Differences in the Response to Glucose.PloS one · 2016Article
- CD18 expression in granulocytes infiltrating the vitreous fluid in patients with diabetic retinopathy.International journal of ophthalmology · 2015Article
- Angiogenic Factors and Cytokines in Diabetic Retinopathy.Journal of clinical & cellular immunology · 2013Article
- Different expression pattern of serum soluble intercellular adhesion molecules-1 and neutrophilic expression of CD18 in patients with diabetic retinopathy.International journal of ophthalmology · 2012Article
- Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathy.Mediators of inflammation · 2012Review
- Leukocyte adhesion molecules in diabetic retinopathy.Journal of ophthalmology · 2012Article
- Neural inflammation and the microglial response in diabetic retinopathy.Journal of ocular biology, diseases, and informatics · 2011Article
- The paradox of the neutrophil's role in tissue injury.Journal of leukocyte biology · 2011Review
- Immunological mechanisms in the pathogenesis of diabetic retinopathy.Seminars in immunopathology · 2008Review
- Structural alterations of the erythrocyte membrane proteins in diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of CD18 on neutrophils from patients with various stages of diabetic retinopathy (DR) and to determine the possibility of using it as a marker of disease development. RESEARCH DESIGN AND
methodsLevels of CD18 on neutrophils were measured by flow cytometry in 10 patients with DR stage 1, 14 patients in stages 2-4, 14 patients in stage 5 and 10 non-diabetic healthy subjects (control).
resultsMean channel fluorescence (MCF) of CD18 on neutrophils from the control, stage 1, stages 2-4 and stage 5 groups were 1.36+/-0.17, 2.99+/-1.44, 3.13+/-1.10 and 4.11+/-1.62, respectively. The difference among them was significant (P=0.00). The highest was from the stage 5 group, then stages 2-4 and stage 1. The least was from the control group (trend test, P=0.00). This trend remained after adjusting for confounding variables. This trend was only significant in type 2 when subjects were divided according to diabetic type, even after adjusting for confounding factors. Multiple linear regression against the level of CD18 MCF by stage of DR and covariates revealed a significant and independent association with the stage of DR (beta=0.33; P=0.01).
conclusionElevated levels of CD18 on neutrophils were present in each stage of DR in type 2 diabetic patients. The more severe the disease, the higher the level was. CD18 may be a marker of the development of DR in type 2 diabetes.
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