ArticleJournal of bioenergetics and biomembranes2006
On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria.
Article in Journal of bioenergetics and biomembranes, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Review
- Article
- A permeability transition in liver mitochondria and liposomes induced by α,ω-dioic acids and Ca(2+).European biophysics journal : EBJ · 2014Article
- Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12.Journal of biomedical science · 2014Article
- Evaluation of potential genotoxicity of HIV entry inhibitors derived from natural sources.PloS one · 2014Article
- Article
- Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity.Brain research · 2011Article
- In Vitro Ultramorphological Assessment of Apoptosis on CEMss Induced by Linoleic Acid-Rich Fraction from Typhonium flagelliforme Tuber.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Palmitic acid induces the opening of a Ca2+-dependent pore in the plasma membrane of red blood cells: the possible role of the pore in erythrocyte lysis.The Journal of membrane biology · 2010Article
- Physiological aspects of the mitochondrial cyclosporin A-insensitive palmitate/Ca2+-induced pore: tissue specificity, age profile and dependence on the animal's adaptation to hypoxia.Journal of bioenergetics and biomembranes · 2009Article
- Titration of cardiolipin by either 10-N-nonyl acridine orange or acridine orange sensitizes the adenine nucleotide carrier to permeability transition.Journal of bioenergetics and biomembranes · 2008Article
- Mitochondrial Ca2+ cycle mediated by the palmitate-activated cyclosporin A-insensitive pore.Journal of bioenergetics and biomembranes · 2007Article
- Ethanolic extract ofResearch in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Palmitic acid (Pal) is known to promote apoptosis (Sparagna G et al (2000) Am J Physiol Heart Circ Physiol 279: H2124-H2132) and its amount in blood and mitochondria increases under some pathological conditions. Yet, the mechanism of the proapoptotic action of Pal has not been elucidated. We present evidence for the involvement of the mitochondrial cyclosporin A-insensitive pore induced by Pal/Ca(2+) complexes in the apoptotic process. Opening of this pore led to a fall of the mitochondrial membrane potential and the release of the proapoptotic signal cytochrome c. The addition of cytochrome c prevented these effects and recovered membrane potential, which is in contrast to the cyclosporin A-sensitive mitochondrial permeability transition pore. Oleic and linoleic acids prevented the Pal/Ca(2+)-induced pore opening in the intact mitochondria, this directly and significantly correlating with the effect of these fatty acids on Pal-induced apoptosis in cells (Hardy S et al (2003) J Biol Chem 278: 31861-31870). The specific probe for cardiolipin, 10-N-nonyl acridine orange, inhibited formation of this pore.
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