ArticleMolecular and cellular biology2006
A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Pangenome-based association testing between a structural variant located upstream of the KIT gene and head depigmentation across a diverse panel of cattle breeds.Genetics, selection, evolution : GSE · 2026Article
- Taurine pangenome uncovers a segmental duplication upstream ofGenome research · 2025Article
- TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene.Nature communications · 2024Article
- Dendritic cell immunoreceptor drives atopic dermatitis by modulating oxidized CaMKII-involved mast cell activation.JCI insight · 2022Article
- Visualizing murine breast and melanoma tumor microenvironment using intravital multiphoton microscopy.STAR protocols · 2021Article
- Regulation of Kit Expression in Early Mouse Embryos and ES Cells.Stem cells (Dayton, Ohio) · 2019Article
- OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts.Cell reports · 2017Article
- Polycomb Responds to Low Levels of Transcription.Cell reports · 2017Article
- Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.PloS one · 2017Article
- Disruption of c-Kit Signaling in Kit(W-sh/W-sh) Growing Mice Increases Bone Turnover.Scientific reports · 2016Article
- Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.Cell death & disease · 2016Article
- Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes.Human molecular genetics · 2015Article
- The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy.The Journal of investigative dermatology · 2015Article
- Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus".Circulation research · 2014Article
- Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats.G3 (Bethesda, Md.) · 2014Article
- Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.Nature immunology · 2013Article
- A model to study the phenotypic changes of interstitial cells of Cajal in gastrointestinal diseases.Gastroenterology · 2010Article
- Green fluorescent protein transgene driven by Kit regulatory sequences is expressed in hematopoietic stem cells.Haematologica · 2009Article
- Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.The American journal of pathology · 2008Article
- Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus.Molecular cell · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Kit receptor tyrosine kinase functions in hematopoiesis, melanogenesis, and gametogenesis and in interstitial cells of Cajal. We previously identified two upstream hypersensitive site (HS) clusters in mast cells and melanocytes. Here we investigated the roles of these 5' HS sequences in Kit expression using transgenic mice carrying Kit-GFP reporter constructs. In these mice there is close correspondence between Kit-GFP reporter and endogenous Kit gene expression in most tissues analyzed. Deletion analysis defined the 5' upstream HS cluster region as critical for Kit expression in mast cells. Furthermore, chromatin immunoprecipitation analysis in mast cells showed that H3 and H4 histone hyperacetylation and RNA polymerase II recruitment within the Kit promoter and in the 5' HS region were associated with Kit expression. Therefore, the 5' upstream hypersensitivity sites appear to be critical components of locus control region-mediated Kit gene activation in mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.