ArticleMolecular and cellular biology2006
Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- FERM domain-containing proteins are active components of the cell nucleus.Life science alliance · 2024Review
- Prolactin levels and breast cancer risk by tumor expression of prolactin-related markers.Breast cancer research : BCR · 2023Article
- The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification.PloS one · 2022Article
- An MDM2 inhibitor achieves synergistic cytotoxic effects with adenoviruses lacking E1B55kDa gene on mesothelioma with the wild-type p53 through augmenting NFI expression.Cell death & disease · 2021Article
- Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland.Frontiers in cell and developmental biology · 2020Review
- Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma.International journal of molecular sciences · 2018Article
- Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes.BMC genomics · 2017Article
- Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.Scientific reports · 2016Article
- Forkhead Box F1 promotes breast cancer cell migration by upregulating lysyl oxidase and suppressing Smad2/3 signaling.BMC cancer · 2016Article
- Article
- Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein.Molecular and cellular biology · 2015Article
- Kinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitors.Stem cells translational medicine · 2014Review
- Article
- JAK-STAT in heterochromatin and genome stability.JAK-STAT · 2013Review
- Type I IFN receptor controls activated TYK2 in the nucleus: implications for EAE therapy.Journal of neuroimmunology · 2013Article
- The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.The American journal of pathology · 2013Article
- IFN signaling: how a non-canonical model led to the development of IFN mimetics.Frontiers in immunology · 2013Article
- Three distinct patterns of histone H3Y41 phosphorylation mark active genes.Cell reports · 2012Article
- Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3.Biochimica et biophysica acta · 2012Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The classical mechanism by which prolactin transduces its signal in mammary epithelial cells is by activation of cytosolic signal transducer and activator of transcription 5 (Stat5) via a plasma membrane-associated prolactin receptor-Janus kinase 2 (Jak2) complex. Here we describe an alternative pathway through which prolactin via Jak2 localized in the nucleus activates the transcription factor nuclear factor 1-C2 (NF1-C2). Previous reports have demonstrated a nuclear localization of Jak2, but the physiologic importance of nuclear Jak2 has not been clear. We demonstrate that nuclear Jak2 regulates the amount of active NF1-C2 through tyrosine phosphorylation and proteasomal degradation. Our data also demonstrate a link between prolactin and p53 as well as the milk gene carboxyl ester lipase through nuclear Jak2 and NF1-C2. Hence, we describe a novel pathway through which nuclear Jak2 is subject to regulation by prolactin in mammary epithelial cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.