ArticleMolecular and cellular biology2006
Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 99 citations in OpenAlex.
- Transcription factor PBX4 regulates limb development and haematopoiesis in mice.Cell proliferation · 2024Article
- Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.Molecular biology and evolution · 2023Article
- Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans.Frontiers in cell and developmental biology · 2022Review
- Gene dosage effects of poly(A) track-engineered hypomorphs.Molecular therapy. Nucleic acids · 2021Article
- MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy.Journal of developmental biology · 2021Review
- NEUROD1 Intrinsically Initiates Differentiation of Induced Pluripotent Stem Cells into Neural Progenitor Cells.Molecules and cells · 2020Article
- Mapping the native interaction surfaces of PREP1 with PBX1 by cross-linking mass-spectrometry and mutagenesis.Scientific reports · 2020Article
- The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells.International journal of molecular sciences · 2019Article
- Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.Scientific reports · 2019Article
- 'Building a perfect body': control of vertebrate organogenesis by PBX-dependent regulatory networks.Genes & development · 2019Review
- MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling.Journal of cellular and molecular medicine · 2018Article
- Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.Pathology oncology research : POR · 2018Article
- Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets.Molecular medicine (Cambridge, Mass.) · 2018Review
- PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.Scientific reports · 2018Article
- Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.Frontiers in endocrinology · 2018Review
- Prep1 prevents premature adipogenesis of mesenchymal progenitors.Scientific reports · 2017Article
- A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.Oncotarget · 2017Article
- Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.Journal of gastrointestinal cancer · 2016Article
- The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.Leukemia research · 2016Article
- The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability.Molecular biotechnology · 2016Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development. To understand the in vivo role of Prep1, we have analyzed an embryonic lethal hypomorphic mutant mouse (Prep1(i/i)). Prep1(i/i) embryos die at embryonic day 17.5 (E17.5) to birth with an overall organ hypoplasia, severe anemia, impaired angiogenesis, and eye anomalies, particularly in the lens and retina. The anemia correlates with delayed differentiation of erythroid progenitors and may be, at least in part, responsible for intrauterine death. At E14.5, Prep1 is present in fetal liver (FL) cMyb-positive cells, whose deficiency causes a marked hematopoietic phenotype. Prep1 is also localized to FL endothelial progenitors, consistent with the observed angiogenic phenotype. Likewise, at the same gestational day, Prep1 is present in the eye cells that bear Pax6, implicated in eye development. The levels of cMyb and Pax6 in FL and in the retina, respectively, are significantly decreased in Prep1(i/i) embryos, consistent with the hematopoietic and eye phenotypes. Concomitantly, Prep1 deficiency results in the overall decrease of protein levels of its related family member Meis1 and its partners Pbx1 and Pbx2. As both Prep1 and Meis interact with Pbx, the overall Prep1/Meis-Pbx DNA-binding activity is strongly reduced in whole Prep1(i/i) embryos and their organs. Our data indicate that Prep1 is an essential gene that acts upstream of and within a Pbx-Meis network that regulates multiple aspects of embryonic development.
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