ArticleMolecular and cellular biology2006
Tissue-specific chromatin modifications at a multigene locus generate asymmetric transcriptional interactions.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster.Nucleic acids research · 2016Article
- Autonomous actions of the human growth hormone long-range enhancer.Nucleic acids research · 2015Article
- Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment.Biochemical and biophysical research communications · 2013Article
- Identification of a secondary promoter within the human B cell receptor component gene hCD79b.The Journal of biological chemistry · 2013Article
- DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function.The Journal of biological chemistry · 2012Article
- An RNA-independent linkage of noncoding transcription to long-range enhancer function.Molecular and cellular biology · 2012Article
- Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Random assortment within mammalian genomes juxtaposes genes with distinct expression profiles. This organization, along with the prevalence of long-range regulatory controls, generates a potential for aberrant transcriptional interactions. The human CD79b/GH locus contains six tightly linked genes with three mutually exclusive tissue specificities and interdigitated control elements. One consequence of this compact organization is that the pituitary cell-specific transcriptional events that activate hGH-N also trigger ectopic activation of CD79b. However, the B-cell-specific events that activate CD79b do not trigger reciprocal activation of hGH-N. Here we utilized DNase I hypersensitive site mapping, chromatin immunoprecipitation, and transgenic models to explore the basis for this asymmetric relationship. The results reveal tissue-specific patterns of chromatin structures and transcriptional controls at the CD79b/GH locus in B cells distinct from those in the pituitary gland and placenta. These three unique transcriptional environments suggest a set of corresponding gene expression pathways and transcriptional interactions that are likely to be found juxtaposed at multiple sites within the eukaryotic genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.