ArticleProceedings of the National Academy of Sciences of the United States of America2006
Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Immunoglobulin free light chains: an inflammatory biomarker of diabetes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Receptor editing and genetic variability in human autoreactive B cells.The Journal of experimental medicine · 2016Article
- Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.The Journal of experimental medicine · 2015Article
- Checkpoints that control B cell development.The Journal of clinical investigation · 2015Review
- Light chain editors of anti-DNA receptors in human B cells.The Journal of experimental medicine · 2014Article
- Antibodies that bind complex glycosaminoglycans accumulate in the Golgi.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.Molecular immunology · 2012Article
- B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome.Journal of clinical immunology · 2012Article
- Central B-cell tolerance: where selection begins.Cold Spring Harbor perspectives in biology · 2012Article
- Selection of individual VH genes occurs at the pro-B to pre-B cell transition.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- HBV life cycle and novel drug targets.Hepatology international · 2011Article
- Alternative mechanisms of receptor editing in autoreactive B cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- B cell receptor editing in tolerance and autoimmunity.Annals of the New York Academy of Sciences · 2011Review
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- Checkpoints in lymphocyte development and autoimmune disease.Nature immunology · 2010Review
- RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes.The Journal of experimental medicine · 2008Article
- Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Editing and escape from editing in anti-DNA B cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.The Journal of experimental medicine · 2008Article
- Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V(L)-J(L)-C(L)) gene clusters.Developmental and comparative immunology · 2008Article
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4 authors.
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Abstract
To investigate the manner in which B cells with lambda light (L) chains undergo receptor editing, we have studied hybridoma panels from 56R/kappa-deleted (kdel) mice. 56R/kdel mice only produce four L chains (lambda1, lambda2, lambda3, and lambdaX). They also have a simplified heavy (H) chain repertoire: All B cells start out with a 56R anti-DNA H chain. A few frankly autoreactive 56R lambda1 cells appear to escape into the periphery, but the majority of the peripheral B cell repertoire in 56R/kdel is made up of B cells expressing the 56R H chain with the lambdaX L chain. Surprisingly, 56R lambdaX B cells are multireactive, binding to a variety of self and nonself antigens, including dsDNA (albeit at reduced affinity compared with the other lambda L chains). Another significant population in the 56R/kdel mouse consists of allelically included B cells that express lambdaX along with another L chain. The multireactivity of both 56R lambdaX and 56R lambdaX/lambda1 receptors could contribute to autoimmunity if these B cells were to become activated. Also found among 56R/kdel hybridomas are clones that have inactivated the H chain and secrete only L chains. These clones may represent products of exhaustive rearrangement. Multireactivity, allelic inclusion, and L chain secretion are three consequences of editing at the lambda locus that may predispose toward the development of autoimmunity.
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