ArticleThe Journal of cell biology2006
Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.Oncogene · 2020Article
- Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.Cancers · 2019Article
- Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies.American journal of human genetics · 2019Article
- Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.Aging cell · 2018Article
- Subunits of human condensins are potential therapeutic targets for cancers.Cell division · 2018Article
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
- A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.Nature medicine · 2012Article
- Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death.Cell death and differentiation · 2011Article
- BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Cell death and differentiation · 2010Article
- Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure.European biophysics journal : EBJ · 2009Article
- Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?Bipolar disorders · 2009Article
- A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.Journal of virology · 2008Article
- BUB1 mediation of caspase-independent mitotic death determines cell fate.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mitotic cell death (MCD) is a prominent but poorly defined form of death that stems from aberrant mitosis. One of the early steps in MCD is premature mitosis and uneven chromatin condensation (UCC). The mechanism underlying this phenomenon is currently unknown. In this study, we show that DNA damage in cells with a compromised p53-mediated G2/M checkpoint triggers the unscheduled activation of cyclin-dependent kinase 1 (Cdk1), activation and chromatin loading of the condensin I complex, and UCC followed by the appearance of multimicronucleated cells, which is evidence of MCD. We demonstrate that these processes engage some of the players of normal mitotic chromatin packaging but not those that drive the apoptotic chromatin condensation. Our findings establish a link between the induction of DNA damage and mitotic abnormalities (UCC) through the unscheduled activation of Cdk1 and recruitment of condensin I. These results demonstrate a clear distinction between the mechanisms that drive MCD-associated and apoptosis-related chromatin condensation and provide mechanistic insights and new readouts for a major cell death process in treated tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.