ArticleThe Journal of general physiology2006
A trapped intracellular cation modulates K+ channel recovery from slow inactivation.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora's Box.International journal of molecular sciences · 2022Review
- Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.The Journal of general physiology · 2021Article
- The activation gate controls steady-state inactivation and recovery from inactivation in Shaker.The Journal of general physiology · 2020Article
- Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.Structure (London, England : 1993) · 2016Article
- Initial steps of inactivation at the K+ channel selectivity filter.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?The Journal of general physiology · 2013Article
- An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.The Journal of general physiology · 2012Article
- Structural correlates of selectivity and inactivation in potassium channels.Biochimica et biophysica acta · 2012Review
- Voltage gated ion channel function: gating, conduction, and the role of water and protons.International journal of molecular sciences · 2012Review
- Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.Annual review of biochemistry · 2011Review
- Conformational changes in the selectivity filter of the open-state KcsA channel: an energy minimization study.Biophysical journal · 2008Article
- Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.Biophysical journal · 2008Article
- Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?Biophysical journal · 2007Article
- Probing the cavity of the slow inactivated conformation of shaker potassium channels.The Journal of general physiology · 2007Article
- Deprotonation by dehydration: the origin of ammonium sensing in the AmtB channel.PLoS computational biology · 2007Article
- Cross talk between activation and slow inactivation gates of Shaker potassium channels.The Journal of general physiology · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Upon depolarization, many voltage-gated potassium channels undergo a time-dependent decrease in conductance known as inactivation. Both entry of channels into an inactivated state and recovery from this state govern cellular excitability. In this study, we show that recovery from slow inactivation is regulated by intracellular permeant cations. When inactivated channels are hyperpolarized, closure of the activation gate traps a cation between the activation and inactivation gates. The identity of the trapped cation determines the rate of recovery, and the ability of cations to promote recovery follows the rank order K+ > NH4+ > Rb+ > Cs+ >> Na+, TMA. The striking similarity between this rank order and that for single channel conductance suggests that these two processes share a common feature. We propose that the rate of recovery from slow inactivation is determined by the ability of entrapped cations to move into a binding site in the channel's selectivity filter, and refilling of this site is required for recovery.
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