ArticleProceedings. Biological sciences2006
Pathogen responses to host immunity: the impact of time delays and memory on the evolution of virulence.
Article in Proceedings. Biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Exploring pathogen population density as a metric for understanding post-COVID infectious disease surges.Frontiers in immunology · 2024Article
- Reservoir host immunology and life history shape virulence evolution in zoonotic viruses.PLoS biology · 2023Article
- Pollen as Bee Medicine: Is Prevention Better than Cure?Biology · 2023Article
- The evolutionary dynamics of viruses: virion release strategies, time delays and fitness minima.Virus evolution · 2021Article
- Incorporating Time Delays in the Mathematical Modelling of the Human Immune Response in Viral Infections.Procedia computer science · 2021Article
- Generalizations of the 'Linear Chain Trick': incorporating more flexible dwell time distributions into mean field ODE models.Journal of mathematical biology · 2019Article
- Ancestral chytrid pathogen remains hypervirulent following its long coevolution with amphibian hosts.Proceedings. Biological sciences · 2019Article
- Parasite resource manipulation drives bimodal variation in infection duration.Proceedings. Biological sciences · 2019Article
- How to prevent viremia rebound? Evidence from a PRRSv data-supported model of immune response.BMC systems biology · 2019Article
- Urinary neopterin levels increase and predict survival during a respiratory outbreak in wild chimpanzees (Taï National Park, Côte d'Ivoire).Scientific reports · 2018Article
- Stochastic variation in the initial phase of bacterial infection predicts the probability of survival ineLife · 2017Article
- The evolutionary and coevolutionary consequences of defensive microbes for host-parasite interactions.BMC evolutionary biology · 2017Article
- Resistance in persisting bat populations after white-nose syndrome invasion.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Codimension-one bifurcation and stability analysis in an immunosuppressive infection model.SpringerPlus · 2016Article
- Computational Studies of the Intestinal Host-Microbiota Interactome.Computation (Basel, Switzerland) · 2015Article
- Disentangling the interaction among host resources, the immune system and pathogens.Ecology letters · 2014Article
- Sustained and transient oscillations and chaos induced by delayed antiviral immune response in an immunosuppressive infection model.Journal of mathematical biology · 2014Article
- An offer you cannot refuse: down-regulation of immunity in response to a pathogen's retaliation threat.Journal of evolutionary biology · 2013Article
- Dances with worms: the ecological and evolutionary impacts of deworming on coinfecting pathogens.Parasitology · 2013Article
- A differential interplay between the expression of Th1/Th2/Treg related cytokine genes in Teladorsagia circumcincta infected DRB1*1101 carrier lambs.Veterinary research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current analytical models of the mammalian immune system typically assume a specialist predator-prey relationship between invading pathogens and the active components of the immune response. However, in reality, the specific immune system is not immediately effective following invasion by a novel pathogen. First, there may be an explicit time delay between infection and immune initiation and, second, there may be a gradual build-up in immune efficacy (for instance, during the period of B-cell affinity maturation) during which the immune response develops, before reaching maximal specificity to the pathogen. Here, we use a novel theoretical approach to show that these processes, together with the presence of long-lived immune memory, decouple the immune response from current pathogen levels, greatly changing the dynamics of the pathogen-immune system interaction and the ability of the immune response to eliminate the pathogen. Furthermore, we use this model to show how distributed primary immune responses combine with immune memory to greatly affect the optimal virulence of the pathogen, potentially resulting in the evolution of highly virulent pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.