ArticleBMC genomics2006
Association of poly-purine/poly-pyrimidine sequences with meiotic recombination hot spots.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.Cell reports · 2024Article
- Extreme clustering of type-1 NF1 deletion breakpoints co-locating with G-quadruplex forming sequences.Human genetics · 2018Article
- The consequences of sequence erosion in the evolution of recombination hotspots.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.Biophysical journal · 2017Article
- Specific modifications of histone tails, but not DNA methylation, mirror the temporal variation of mammalian recombination hotspots.Genome biology and evolution · 2014Article
- Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148.Human molecular genetics · 2012Article
- Searching microsatellites in DNA sequences: approaches used and tools developed.Physiology and molecular biology of plants : an international journal of functional plant biology · 2012Article
- Important characteristics of sequence-specific recombination hotspots in Schizosaccharomyces pombe.Genetics · 2011Article
- High recombination rates and hotspots in a Plasmodium falciparum genetic cross.Genome biology · 2011Article
- Recurrent distal 7q11.23 deletion including HIP1 and YWHAG identified in patients with intellectual disabilities, epilepsy, and neurobehavioral problems.American journal of human genetics · 2010Article
- Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?Human mutation · 2010Article
- Genome-wide analysis of conservation and divergence of microsatellites in rice.Molecular genetics and genomics : MGG · 2009Article
- Novel nucleotide sequence motifs that produce hotspots of meiotic recombination in Schizosaccharomyces pombe.Genetics · 2009Article
- High frequency of microsatellites in S. cerevisiae meiotic recombination hotspots.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeiotic recombination events have been found to concentrate in 1-2.5 kilo base regions, but these recombination hot spots do not share a consensus sequence and why they occur at specific sites is not fully understood. Some previous evidence suggests that poly-purine/poly-pyrimidine (poly-pu/py) tracts (PPTs), a class of sequence with distinctive biochemical properties, could be involved in recombination, but no general association of PPTs with meiotic recombination hot spots has previously been reported.
resultsWe used computational methods to investigate in detail the relationship between PPTs and hot spots. We show statistical associations of PPT frequency with hot spots of meiotic recombination initiating lesions, double-strand breaks, in the genome of the yeast S. cerevisiae and with experimentally well characterized human meiotic recombination hot spots. Supporting a possible role of poly-pu/py-rich sequences in hot spot recombination, we also found that all three single nucleotide polymorphisms previously shown to be associated with human hot spot activity changes occur within sequence contexts of 14 bp or longer that are 85% or more poly-pu/py and at least 70% G/C. These polymorphisms are all close to the hot spot mid points. Comparing the sequences of experimentally characterized human hot spots with the orthologous regions of the chimpanzee genome previously shown not to contain hot spots, we found that in all five cases in which comparisons for the hot spot central regions are possible with publicly available sequence data, there are differences near the human hot spot mid points within sequences 14 bp or longer consisting of more than 80% poly-pu/py and at least 50% G/C.
conclusionOur results, along with previous evidence for the unique biochemical properties and recombination-stimulating potential of poly-pu/py-rich sequences, suggest that the possible functional involvement of this type of sequence in meiotic recombination hot spots deserves further experimental exploration.
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