ArticleBMC infectious diseases2006
The frequency of genes encoding three putative group B streptococcal virulence factors among invasive and colonizing isolates.
Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Group B streptococcus virulence factors associated with different clinical syndromes: Asymptomatic carriage in pregnant women and early-onset disease in the newborn.Frontiers in microbiology · 2023Article
- Antimicrobial Resistance and Virulence Genes ofJournal of veterinary research · 2022Article
- Virulence Profiles and Antimicrobial Resistance of Streptococcus agalactiae Infective and Colonizing Strains from Argentina.Current microbiology · 2022Article
- Epidemiology, Antimicrobial Resistance, and Virulence Determinants of Group BFrontiers in microbiology · 2022Article
- Virulence factors and antibiotic resistance properties of Streptococcus species isolated from hospital cockroaches.3 Biotech · 2021Article
- Analysis of virulence factors and antibiotic resistance genes in group B streptococcus from clinical samples.BMC infectious diseases · 2021Article
- Prevalence, serotypes and virulence genes of Streptococcus agalactiae isolated from pregnant women with 35-37 weeks of gestation.BMC infectious diseases · 2021Article
- Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) Streptococcus agalactiae in Korea Based on Whole Genome Sequences.Annals of laboratory medicine · 2020Article
- Repetitive cellulitis caused byIDCases · 2020Article
- Status of group B streptococcal vaccine development.Clinical and experimental vaccine research · 2018Article
- Antimicrobial susceptibility profiles, serotype distribution and virulence determinants among invasive, non-invasive and colonizing Streptococcus agalactiae (group B streptococcus) from Malaysian patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Phenotypic and genotypic characterization of Streptococcus agalactiae in pregnant women. First study in a province of Argentina.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013Article
- Genotypes and virulence genes in group B streptococcus isolated in the maternity hospital, Kuwait.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Article
- Group B streptococci causing neonatal infections in barcelona are a stable clonal population: 18-year surveillance.Journal of clinical microbiology · 2011Article
- Group B streptococcus serotype prevalence in reproductive-age women at a tertiary care military medical center relative to global serotype distribution.BMC infectious diseases · 2010Article
- Epidemiology of and prenatal molecular distinction between invasive and colonizing group B streptococci in The Netherlands and Taiwan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease.Vaccine · 2008Article
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7 authors.
Funding
Abstract
backgroundGroup B Streptococcus (GBS) causes severe infections in very young infants and invasive disease in pregnant women and adults with underlying medical conditions. GBS pathogenicity varies between and within serotypes, with considerable variation in genetic content between strains. Three proteins, Rib encoded by rib, and alpha and beta C proteins encoded by bca and bac, respectively, have been suggested as potential vaccine candidates for GBS. It is not known, however, whether these genes occur more frequently in invasive versus colonizing GBS strains.
methodsWe screened 162 invasive and 338 colonizing GBS strains from different collections using dot blot hybridization to assess the frequency of bca, bac and rib. All strains were defined by serotyping for capsular type, and frequency differences were tested using the Chi square test.
resultsGenes encoding the beta C protein (bac) and Rib (rib) occurred at similar frequencies among invasive and colonizing isolates, bac (20% vs. 23%), and rib (28% vs. 20%), while the alpha (bca) C protein was more frequently found in colonizing strains (46%) vs, invasive (29%). Invasive strains were associated with specific serotype/gene combinations.
conclusionNovel virulence factors must be identified to better understand GBS disease.
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