ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarray.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 50 citations in OpenAlex.
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- Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella.Veterinary research · 2014Review
- Genetic variations of TAP1 gene exon 3 affects gene expression and Escherichia coli F18 resistance in piglets.International journal of molecular sciences · 2014Article
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- Chicken innate immune response to oral infection with Salmonella enterica serovar Enteritidis.Veterinary research · 2013Article
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- Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene.International journal of biological sciences · 2012Article
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- Methods for transcriptomic analyses of the porcine host immune response: application to Salmonella infection using microarrays.Veterinary immunology and immunopathology · 2010Review
- Response of swine spleen to Streptococcus suis infection revealed by transcription analysis.BMC genomics · 2010Article
- Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach.BMC genomics · 2009Article
- Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44 K Agilent microarray.BMC genomics · 2008Article
- Analysis of porcine transcriptional response to Salmonella enterica serovar Choleraesuis suggests novel targets of NFkappaB are activated in the mesenteric lymph node.BMC genomics · 2008Article
- Discovery of porcine microRNAs and profiling from skeletal muscle tissues during development.PloS one · 2008Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the transcriptional response to pathogenic bacterial infection within food animals is of fundamental and applied interest. To determine the transcriptional response to Salmonella enterica serovar Choleraesuis (SC) infection, a 13,297-oligonucleotide swine array was used to analyze RNA from control, 24-h postinoculation (hpi), and 48-hpi porcine lung tissue from pigs infected with SC. In total, 57 genes showed differential expression (p < 0.001; false discovery rate = 12%). Quantitative real-time PCR (qRT-PCR) of 61 genes was used to confirm the microarray results and to identify pathways responding to infection. Of the 33 genes identified by microarray analysis as differentially expressed, 23 were confirmed by qRT-PCR results. A novel finding was that two transglutaminase family genes (TGM1 and TGM3) showed dramatic increases in expression postinoculation; combined with several other apoptotic genes, they indicated the induction of apoptotic pathways during SC infection. A predominant T helper 1-type immune response occurred during infection, with interferon gamma (IFNG) significantly increased at 48 hpi. Genes induced by IFNs (GBP1, GBP2, C1S, C1R, MHC2TA, PSMB8, TAP1, TAP2) showed increased expression during porcine lung infection. These data represent the first thorough investigation of gene regulation pathways that control an important porcine respiratory and foodborne bacterial infection.
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