ArticlePediatric radiology2006
Sonographic evaluation of inflammatory bowel disease: a prospective, blinded, comparative study.
Article in Pediatric radiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper.Journal of pediatric gastroenterology and nutrition · 2026Pooled it
- Diagnostic Accuracy of Transabdominal Ultrasound in Detecting Intestinal Inflammation in Paediatric IBD Patients-a Systematic Review.Journal of Crohn's & colitis · 2019Pooled it
- Bowel Wall Thickness Cutoff Value for Assessing Inflammatory Bowel Disease Activity Using Intestinal Ultrasonography in Children.Inflammatory bowel diseases · 2026Article
- Early intestinal ultrasound findings predict remission and treatment response at 1 year in pediatric Crohn's disease.Journal of Crohn's & colitis · 2026Article
- The Role of Intestinal Ultrasonography in Children with Inflammatory Bowel Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Ultrasound of the bowel with a focus on IBD: the new best practice.Abdominal radiology (New York) · 2025Review
- Intestinal ultrasound measurement of bowel wall thickness can be used as a sole marker for defining anti-TNF maintenance therapy failure in Crohn's disease.Therapeutic advances in gastroenterology · 2025Article
- Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives.Children (Basel, Switzerland) · 2024Review
- Predicting Treatment Response in Inflammatory Bowel Diseases: Cross-Sectional Imaging Markers.Journal of clinical medicine · 2023Review
- Basic practices for gastrointestinal ultrasound.Journal of medical ultrasonics (2001) · 2023Review
- Observational
- Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study.Journal of gastroenterology · 2019Article
- Defining the ultrasound longitudinal natural history of newly diagnosed pediatric small bowel Crohn disease treated with infliximab and infliximab-azathioprine combination therapy.Pediatric radiology · 2017Article
- Can ultrasound be used as the primary imaging in children with suspected Crohn disease?Pediatric radiology · 2017Article
- Assessment of Crohn's disease activity by Doppler sonography.Saudi medical journal · 2017Article
- Advanced multimodality imaging of inflammatory bowel disease in 2015: An update.World journal of radiology · 2016Review
- Prospective cohort study of ultrasound-ultrasound and ultrasound-MR enterography agreement in the evaluation of pediatric small bowel Crohn disease.Pediatric radiology · 2016Article
- Inflammatory bowel disease imaging: Current practice and future directions.World journal of gastroenterology · 2016Review
- Ultrasound features of pediatric Crohn disease: a guide for case interpretation.Pediatric radiology · 2015Review
- Ultrasonographic imaging of inflammatory bowel disease in pediatric patients.World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren with inflammatory bowel disease (IBD) undergo invasive and repeated investigations, including contrast radiology and endoscopy.
objectiveTo assess transabdominal sonography of the colon and distal ileum compared to colonoscopy and barium radiology in known or suspected IBD. MATERIALS AND
methodsA prospectively recruited cohort of 44 children (median age 12 years, range 3.5-16.5 years; 24 males) underwent transabdominal sonography prior to colonoscopy (n=33) or barium follow-through (n=25). Diagnoses were: Crohn disease (n=25), ulcerative colitis (n=12), indeterminate colitis (n=1), normal (n=6).
resultsBowel wall thickness (BWT) and endoscopic severity were compared in 153 colonic segments. No difference was found between normal and mildly affected segments. BWT was less in normal bowel than moderate (P<0.001) or severe (P<0.001) lesions. Where BWT was >2.9 mm, sensitivity for moderate/severe disease was 48%, specificity 93%, positive predictive value 83% (likelihood ratio 7). Barium radiology showed terminal ileum abnormality in ten patients (40%). Where ileal BWT was >2.5 mm, comparative sensitivity was 75%, specificity 92%, positive predictive value 88% (likelihood ratio 9). Superior mesenteric artery Doppler did not correlate with disease severity.
conclusionIncreased BWT has good positive predictive value for moderate/severe disease in the colon proximal to the rectum (>3 mm), and terminal ileum (>2.5 mm). BWT below this cannot exclude moderate/severe mucosal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.