ArticleEMBO reports2006
HoxB domain induction silences DNA replication origins in the locus and specifies a single origin at its boundary.
Article in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.Nature communications · 2015Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.PloS one · 2015Article
- Epigenetic landscape for initiation of DNA replication.Chromosoma · 2014Review
- Replication origin selection regulates the distribution of meiotic recombination.Molecular cell · 2014Article
- Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs.Nature structural & molecular biology · 2012Article
- Regulation of DNA replication during development.Development (Cambridge, England) · 2012Review
- USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator.PLoS biology · 2012Article
- DNA replication fading as proliferating cells advance in their commitment to terminal differentiation.Scientific reports · 2012Article
- Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.The Journal of cell biology · 2011Article
- Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.PLoS computational biology · 2011Article
- Genome-wide depletion of replication initiation events in highly transcribed regions.Genome research · 2011Article
- Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.Genome research · 2011Article
- Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.Nature · 2011Article
- Genomic approaches to the initiation of DNA replication and chromatin structure reveal a complex relationship.Briefings in functional genomics · 2011Review
- Eukaryotic DNA replication origins: many choices for appropriate answers.Nature reviews. Molecular cell biology · 2010Review
- Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.Molecular and cellular biology · 2010Article
- Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions.EMBO reports · 2010Article
- Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome.Genome research · 2010Article
- Programming DNA replication origins and chromosome organization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Review
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In multicellular organisms, changes in the DNA replication programme could act to integrate differentiation with cell division in various developmental and transcriptional contexts. Here, we have addressed the use of DNA replication origins during differentiation in the HoxB domain-a cluster of nine genes developmentally regulated in a collinear manner. In undifferentiated mouse P19 cells, we detected several DNA replication origins in the 100 kb HoxB locus, indicating a relaxed origin use when the locus is transcriptionally silent. By contrast, in retinoic-acid-induced differentiated cells, when HoxB transcription is activated, a general silencing of DNA replication origins occurs in the locus except one located downstream of Hoxb1, at the 3' boundary of the HoxB domain. Silencing of the replication origins is associated with histone hyperacetylation, whereas the active Hoxb1 origin persists as a hypoacetylated island. These findings provide direct evidence for the differentiated use of origins in HoxB genes, and we suggest that this regulation might contribute to the regulated expression of HoxB genes during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.