ArticleNucleic acids research2006
TOM: a web-based integrated approach for identification of candidate disease genes.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Identification of infectious disease-associated host genes using machine learning techniques.BMC bioinformatics · 2019Article
- RecRWR: a recursive random walk method for improved identification of diseases.BioMed research international · 2015Article
- Systems genetics in "-omics" era: current and future development.Theory in biosciences = Theorie in den Biowissenschaften · 2013Review
- Candidate gene prioritization.Molecular genetics and genomics : MGG · 2012Review
- Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR.Bioinformatics (Oxford, England) · 2010Article
- Bioinformatic tools for identifying disease gene and SNP candidates.Methods in molecular biology (Clifton, N.J.) · 2010Review
- Article
- A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case.Bioinformatics (Oxford, England) · 2009Article
- Gene-disease relationship discovery based on model-driven data integration and database view definition.Bioinformatics (Oxford, England) · 2009Article
- Integrating computational biology and forward genetics in Drosophila.PLoS genetics · 2009Article
- CANDID: a flexible method for prioritizing candidate genes for complex human traits.Genetic epidemiology · 2008Article
- Article
- ENDEAVOUR update: a web resource for gene prioritization in multiple species.Nucleic acids research · 2008Article
- Conserved co-expression for candidate disease gene prioritization.BMC bioinformatics · 2008Article
- Prediction of human disease genes by human-mouse conserved coexpression analysis.PLoS computational biology · 2008Article
- FunSimMat: a comprehensive functional similarity database.Nucleic acids research · 2008Article
- FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease.Genome biology · 2008Article
- Candidate gene identification approach: progress and challenges.International journal of biological sciences · 2007Review
- Update of the G2D tool for prioritization of gene candidates to inherited diseases.Nucleic acids research · 2007Article
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8 authors.
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Abstract
The massive production of biological data by means of highly parallel devices like microarrays for gene expression has paved the way to new possible approaches in molecular genetics. Among them the possibility of inferring biological answers by querying large amounts of expression data. Based on this principle, we present here TOM, a web-based resource for the efficient extraction of candidate genes for hereditary diseases. The service requires the previous knowledge of at least another gene responsible for the disease and the linkage area, or else of two disease associated genetic intervals. The algorithm uses the information stored in public resources, including mapping, expression and functional databases. Given the queries, TOM will select and list one or more candidate genes. This approach allows the geneticist to bypass the costly and time consuming tracing of genetic markers through entire families and might improve the chance of identifying disease genes, particularly for rare diseases. We present here the tool and the results obtained on known benchmark and on hereditary predisposition to familial thyroid cancer. Our algorithm is available at http://www-micrel.deis.unibo.it/~tom/.
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