ArticleProceedings of the National Academy of Sciences of the United States of America2006
Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Biological and genomic analysis of a symbiotic nitrogen fixation defective mutant inFrontiers in plant science · 2023Article
- An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants.Journal of visualized experiments : JoVE · 2017Article
- Article
- Identification of potential antisense transcripts in rice using conventional microarray.Molecular biotechnology · 2012Article
- Cooperation between Rb and Arf in suppressing mouse retinoblastoma.The Journal of clinical investigation · 2012Article
- miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.Genes & development · 2011Article
- Bayesian Nonparametric Hidden Markov Models with application to the analysis of copy-number-variation in mammalian genomes.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2011Article
- High-throughput identification of genetic markers using representational oligonucleotide microarray analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.Genes & development · 2010Article
- Allelic genome structural variations in maize detected by array comparative genome hybridization.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Construction and application of a zebrafish array comparative genomic hybridization platform.Genes, chromosomes & cancer · 2009Article
- Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays.BMC genomics · 2008Article
- Genomic copy number and expression variation within the C57BL/6J inbred mouse strain.Genome research · 2008Article
- Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.The EMBO journal · 2007Article
- Identification of alterations in DNA copy number in host stromal cells during tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers.PLoS genetics · 2006Article
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Authors and funding
12 authors.
Funding
Abstract
Genomic amplifications and deletions, the consequence of somatic variation, are a hallmark of human cancer. Such variation has also been observed between "normal" individuals, as well as in individuals with congenital disorders. Thus, copy number measurement is likely to be an important tool for the analysis of genetic variation, genetic disease, and cancer. We developed representational oligonucleotide microarray analysis, a high-resolution comparative genomic hybridization methodology, with this aim in mind, and reported its use in the study of humans. Here we report the development of a representational oligonucleotide microarray analysis microarray for the genomic analysis of the mouse, an important model system for many genetic diseases and cancer. This microarray was designed based on the sequence assembly MM3, and contains approximately 84,000 probes randomly distributed throughout the mouse genome. We demonstrate the use of this array to identify copy number changes in mouse cancers, as well to determine copy number variation between inbred strains of mice. Because restriction endonuclease digestion of genomic DNA is an integral component of our method, differences due to polymorphisms at the restriction enzyme cleavage sites are also observed between strains, and these can be useful to follow the inheritance of loci between crosses of different strains.
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