ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Quality of life in GERD patients: medical treatment versus antireflux surgery.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05579587 (Transoral Incisionless Fundoplication), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) Patients
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Impact of second-generation transoral incisionless fundoplication on atypical GERD symptoms: a systematic review and meta-analysis.Gastrointestinal endoscopy · 2023Pooled it
- Surgical treatment of GERD: systematic review and meta-analysis.Surgical endoscopy · 2021Pooled it
- Systematic review: laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors.World journal of gastroenterology · 2014Pooled it
- Guidelines for surgical treatment of gastroesophageal reflux disease.Surgical endoscopy · 2010Guideline
- Efficacy of transoral fundoplication for treatment of chronic gastroesophageal reflux disease incompletely controlled with high-dose proton-pump inhibitors therapy: a randomized, multicenter, open label, crossover study.BMC gastroenterology · 2014Trial
- Long-term quality of life improvement in subjects with healed erosive esophagitis: treatment with lansoprazole.Digestive diseases and sciences · 2010Trial
- Barrett's Epithelium to Esophageal Adenocarcinoma: Is There a "Point of No Return"?Frontiers in genetics · 2021Article
- Mind the Gap: Current Treatment Alternatives for GERD Patients Failing Medical Treatment and Not Ready for a Fundoplication.Surgical laparoscopy, endoscopy & percutaneous techniques · 2020Review
- Article
- Diagnostic Efficacy of 24-hr Esophageal pH Monitoring in Patients with Refractory Gastroesophageal Reflux Disease.Open access Macedonian journal of medical sciences · 2018Article
- Comparison of Stretta procedure and toupet fundoplication for gastroesophageal reflux disease-related extra-esophageal symptoms.World journal of gastroenterology · 2015Article
- Update on fundoplication for the treatment of GERD.Current gastroenterology reports · 2012Review
- SSAT maintenance of certification: literature review on gastroesophageal reflux disease and hiatal hernia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Review
- Evaluation of clinical outcome after laparoscopic antireflux surgery in clinical practice: still a controversial issue.Minimally invasive surgery · 2011Article
- Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery.Surgical endoscopy · 2009Article
- The use of medication after laparoscopic antireflux surgery.Surgical endoscopy · 2009Article
- Preoperative lower esophageal sphincter manometry data neither impact manifestations of GERD nor outcome after laparoscopic Nissen fundoplication.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Symptom-focused results after laparoscopic fundoplication for refractory gastroesophageal reflux disease--a prospective study.Langenbeck's archives of surgery · 2008Article
- Tailored antireflux surgery.The journal of nutrition, health & aging · 2008Article
- Antireflux transoral incisionless fundoplication using EsophyX: 12-month results of a prospective multicenter study.World journal of surgery · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medical and surgical treatments are able to improve symptoms in patients with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the outcome in GERD patients without therapy, under continuous medical treatment, and after laparoscopic antireflux surgery. Five hundred seventy-nine consecutive patients underwent medical or surgical treatment for GERD-induced symptoms. Patients were studied in detail before and after treatment by means of a symptom questionnaire, endoscopy, esophageal manometry, 24-hour esophageal pH monitoring, and a barium esophagogram. In addition, quality of life was measured by the means of the Gastrointestinal Quality of Life Index (GIQLI) and the Health-Related Quality of Life (HRQL) questionnaire. Surgery was indicated and performed in 351 patients with persistent or recurrent GERD symptoms and/or complications, and in patients preferring surgery to medical treatment, despite the use of an adequate medication. The remaining 228 patients were treated with proton pump inhibitors (PPI) in the standard dose, or if required, the double dose. The outcome was assessed 3 and 12 months after treatment. While symptoms and quality of life were highly impaired in GERD patients without therapy compared with normal people, a significant improvement was obtained by PPI therapy. Following surgery, quality of life was normalized in all subsections and was significantly higher compared with the medically treated group. These results stayed constant in short-term and intermediate follow-up. Medical and surgical therapies are both able to improve symptoms and quality of life in GERD patients. Nevertheless, the outcome is significantly better following surgery. It can be suggested that surgical treatment may be the more successful therapy in the long-term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.