ArticleBiochemical genetics1991
A molecular genetic linkage map of mouse chromosome 19, including the lpr, Ly-44, and Tdt genes.
Article in Biochemical genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome.Journal of human immunity · 2026Article
- Research progress on the relationship between the TdT gene and autoimmune diseases.Frontiers in immunology · 2026Review
- Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases.Cell death & disease · 2022Review
- Crosstalk between Fas and S1PThe Japanese dental science review · 2019Review
- Autoimmunity: twenty years in the Fas lane.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Perforin-mediated target-cell death and immune homeostasis.Nature reviews. Immunology · 2006Review
- Functional significance of the perforin/granzyme cell death pathway.Nature reviews. Immunology · 2002Review
- Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells.Immunology · 2002Article
- The Fas signaling connection between autoimmunity and embryonic lethality.Journal of clinical immunology · 2001Review
- Differential splicing in mouse thymus generates two forms of terminal deoxynucleotidyl transferase.Nucleic acids research · 1993Article
- A new allele at the lpr gene on mouse chromosome 19 expresses properties different from the original recessive mutation.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- T cell repertoire and autoimmune diseases.Immunologic research · 1993Review
- Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.The Journal of experimental medicine · 1992Article
- A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes.Biochemical genetics · 1992Article
- Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations.Biochemical genetics · 1992Article
- Mouse chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.Springer seminars in immunopathology · 1992Review
- Mouse chromosome 19.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse lpr gene, which is an autosomal recessive gene causing autoimmune disease with features of human systemic lupus erythematosus and eventually death from severe immune-complex glomerulonephritis, has been mapped on chromosome 19. To determine its exact chromosomal location, a three-point backcross was carried out by mating (MRL/MpJ-lpr/lpr x MOL-MIT)F1 x MRL/MpJ-lpr/lpr using the genes Ly-44 (lymphocyte differentiation antigen-44) and Tdt (terminal deoxynucleotidyl transferase) as markers. The following order of genes is proposed, with the distances between genes given in parentheses: centromere-Ly-44 (19.3 cM)-lpr (6.1 cM)-Tdt-telomere. The Ly-44a and Tdta alleles are found in all laboratory strains and in the wild Western European subspecies, domesticus and brevirostris. In contrast, the Ly-44b and Tdtb alleles are found in some Asian subspecies, Chinese mice of wild origin, yamashinai and molossinus. Furthermore the third Tdt allele, Tdtc, is detected in castaneus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.