ArticleJournal of applied physiology (Bethesda, Md. : 1985)2006
Myosin and actin expression and oxidation in aging muscle.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- Effects of ageing on single muscle fibre contractile function following short-term immobilisation.The Journal of physiology · 2011Trial
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- Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility and Aging (SOMMA).medRxiv : the preprint server for health sciences · 2023Article
- Effect ofFrontiers in nutrition · 2023Article
- Protein Oxidation in Muscle Foods: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2021Review
- Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.Diagnostics (Basel, Switzerland) · 2020Article
- The Effects of Calcium-Oxidative medicine and cellular longevity · 2020Article
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.Journal of cachexia, sarcopenia and muscle · 2018Article
- Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading: impact of microRNA-31.The Journal of physiology · 2018Article
- High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice.PloS one · 2018Article
- p49/STRAP, a Serum Response Factor Binding Protein (SRFBP1), Is Involved in the Redistribution of Cytoskeletal F-Actin Proteins during Glucose Deprivation.The journal of nutrition, health & aging · 2017Article
- Article
- Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Improved single muscle fiber quality in the oldest-old.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.Aging cell · 2016Article
- Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality.PloS one · 2016Article
- Oxidative proteome alterations during skeletal muscle ageing.Redox biology · 2015Article
- Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.Free radical biology & medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
While the age-related loss in muscle mass partially explains the decline in strength, other yet undefined mechanisms contribute. This study investigates whether changes in myosin-actin stoichiometry and oxidative modification could help explain the decrement in muscle strength with aging. Protein expression and oxidation were evaluated in myosin and actin isolated from the soleus and semimembranosus muscles from young adult, old, and very old Fischer 344 rats. In the soleus muscle, actin and myosin content did not change with aging. In the semimembranosus, actin content was stable, but myosin exhibited decreased content in muscles from very old rats, resulting in a decrease in the myosin-to-actin ratio. 3-Nitrotyrosine and 4-hydroxy-2-nonenal were used as markers of protein oxidative damage. Although myosin and actin are modified with 3-nitrotyrosine and 4-hydroxy-2-nonenal, the extent of chemical modification does not increase with age. The results suggest that the decline in force production with age is not due to the accumulation of these two specific markers of protein oxidation on the myofibrillar proteins. Additionally, age-dependent changes in myofibrillar stoichiometry do not contribute to the decline in force production in the soleus, but may play a role in the semimembranosus with advanced age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.