ArticleProceedings of the National Academy of Sciences of the United States of America2006
Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 130 citations in OpenAlex.
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- DNMT3A-dependent DNA methylation shapes the endothelial enhancer landscape.Nucleic acids research · 2025Article
- Stress Molecular Signaling in Interaction With Cognition.Biological psychiatry · 2025Review
- Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness.Clinical epigenetics · 2024Article
- SSBlazer: a genome-wide nucleotide-resolution model for predicting single-strand break sites.Genome biology · 2024Article
- Sperm chromatin accessibility's involvement in the intergenerational effects of stress hormone receptor activation.Translational psychiatry · 2023Article
- Enzyme-free targeted DNA demethylation using CRISPR-dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression.Nature protocols · 2022Review
- Article
- The pediatric buccal epigenetic clock identifies significant ageing acceleration in children with internalizing disorder and maltreatment exposure.Neurobiology of stress · 2021Article
- Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation.Clinical epigenetics · 2021Article
- Naturalistic Stress Hormone Levels Drive Cumulative Epigenomic Changes along the Cellular Lifespan.International journal of molecular sciences · 2021Article
- A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders.Neurobiology of stress · 2020Article
- Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus.Clinical epigenetics · 2019Article
- Gene activation precedes DNA demethylation in response to infection in human dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- [Environment and epigenetics].Der Nervenarzt · 2019Review
- Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.Nucleic acids research · 2017Article
- Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation.Frontiers in psychology · 2017Article
- Dissecting the molecular mechanisms of gene x environment interactions: implications for diagnosis and treatment of stress-related psychiatric disorders.European journal of psychotraumatology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and controversial. Here, we present a detailed characterization of the demethylation of an endogenous gene in cultured cells. This demethylation is triggered in a regulatory region by a transcriptional activator, the glucocorticoid receptor. We show that DNA demethylation is an active process, occurring independently of DNA replication, and in a distributive manner without concerted demethylation of cytosines on both strands. We demonstrate that the DNA backbone is cleaved 3' to the methyl cytidine during demethylation, and we suggest that a DNA repair pathway may therefore be involved in this demethylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.