ArticleBMC infectious diseases2006
Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy.
Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Age is not just a number: Naive T cells increase their ability to persist in the circulation over time.PLoS biology · 2018Article
- Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation.Oncoimmunology · 2016Article
- Supranormal thymic output up to 2 decades after HIV-1 infection.AIDS (London, England) · 2016Article
- Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Incomplete immune reconstitution despite virologic suppression in HIV-1 infected children and adolescents.AIDS (London, England) · 2015Article
- Changes in cellular immune activation and memory T-cell subsets in HIV-infected Zambian children receiving HAART.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Predicting patterns of long-term CD4 reconstitution in HIV-infected children starting antiretroviral therapy in sub-Saharan Africa: a cohort-based modelling study.PLoS medicine · 2013Article
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies.Journal of translational medicine · 2013Review
- Immune Reconstitution Syndrome in HIV-1 infected children - a study from India.Indian journal of pediatrics · 2011Article
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6 authors.
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Abstract
backgroundRecent advances in characterizing the immune recovery of HIV-1-infected people have highlighted the importance of the thymus for peripheral T-cell diversity and function. The aim of this study was to investigate differences in immune reconstitution profiles after highly active antiretroviral therapy (HAART) between HIV-children and adults.
methodsHIV patients were grouped according to their previous clinical and immunological status: 9 HIV-Reconstituting-adults (HIV-Rec-adults) and 10 HIV-Reconstituting-children (HIV-Rec-children) on HAART with viral load (VL) <or=400 copies/ml and CD4+ >or=500 cells/microL at least during 6 months before the study and CD4+ <or=300 cells/microL anytime before. Fifteen healthy-adults and 20 healthy-children (control subjects) were used to calculate Z-score values to unify value scales between children and adults to make them comparable.
resultsHIV-Rec-children had higher T-cell receptor excision circles (TREC) and lower interleukin (IL)-7 levels than HIV-Rec-adults (p < 0.05). When we analyzed Z-score values, HIV-Rec-children had higher TREC Z-score levels (p = 0.03) than HIV-Rec-adults but similar IL-7 Z-score levels. Regarding T-cell subsets, HIV-Rec-children had higher naïve CD4+ (CD4+CD45RA hi+CD27+), naïve CD8+ (CD8+CD45RA hi+CD27+), and memory CD8+ (CD8+CD45RO+) cells/microl than HIV-Rec-adults, but similar memory CD4+ (CD4+CD45RO+) counts. HIV-Rec-children had lower naïve CD8+ Z-score values than HIV-Rec-adults (p = 0.05).
conclusionOur data suggest that HIV-Rec-children had better thymic function than HIV-Rec-adults and this fact affects the peripheral T-cell subsets. Thus, T-cell recovery after HAART in HIV-Rec-adults could be the consequence of antigen-independent peripheral T-cell expansion while in HIV-Rec-children thymic output could play a predominant role in immune reconstitution.
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