ArticlePLoS genetics2006
Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes.PLoS genetics · 2025Article
- Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.International journal of molecular sciences · 2024Article
- SETDB2 interacts with BUBR1 to induce accurate chromosome segregation independently of its histone methyltransferase activity.FEBS open bio · 2024Article
- ThemicroPublication biology · 2022Article
- Upgraded CRISPR/Cas9 tools for tissue-specific mutagenesis inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.Cancer science · 2020Article
- Supernumerary B chromosomes of Aegilops speltoides undergo precise elimination in roots early in embryo development.Nature communications · 2020Article
- The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.PLoS genetics · 2019Article
- Article
- CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model.Cancer science · 2017Article
- Histone storage and deposition in the early Drosophila embryo.Chromosoma · 2015Review
- CRISPR/Cas9 mediates efficient conditional mutagenesis in Drosophila.G3 (Bethesda, Md.) · 2014Article
- Centromeres and kinetochores of Brassicaceae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Review
- Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm.PLoS biology · 2012Article
- A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.PloS one · 2012Article
- Loss of centromeric histone H3 (CENH3) from centromeres precedes uniparental chromosome elimination in interspecific barley hybrids.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Drosophila CENP-C is essential for centromere identity.Chromosoma · 2011Article
- Article
- Article
- The rapidly evolving centromere-specific histone has stringent functional requirements in Arabidopsis thaliana.Genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The centromere/kinetochore complex plays an essential role in cell and organismal viability by ensuring chromosome movements during mitosis and meiosis. The kinetochore also mediates the spindle attachment checkpoint (SAC), which delays anaphase initiation until all chromosomes have achieved bipolar attachment of kinetochores to the mitotic spindle. CENP-A proteins are centromere-specific chromatin components that provide both a structural and a functional foundation for kinetochore formation. Here we show that cells in Drosophila embryos homozygous for null mutations in CENP-A (CID) display an early mitotic delay. This mitotic delay is not suppressed by inactivation of the DNA damage checkpoint and is unlikely to be the result of DNA damage. Surprisingly, mutation of the SAC component BUBR1 partially suppresses this mitotic delay. Furthermore, cid mutants retain an intact SAC response to spindle disruption despite the inability of many kinetochore proteins, including SAC components, to target to kinetochores. We propose that SAC components are able to monitor spindle assembly and inhibit cell cycle progression in the absence of sustained kinetochore localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.