ReviewJournal of molecular evolution2006
The coevolution of genes and genetic codes: Crick's frozen accident revisited.
Review in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 79 citations in OpenAlex.
- The genetic code at the balance point of error and demand.PLoS computational biology · 2026Article
- Order of amino acid recruitment into the genetic code resolved by last universal common ancestor's protein domains.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Order of amino acid recruitment into the genetic code resolved by Last Universal Common Ancestor's protein domains.bioRxiv : the preprint server for biology · 2024Article
- The Genetic Code Assembles via Division and Fusion, Basic Cellular Events.Life (Basel, Switzerland) · 2023Article
- Self-similarity and the maximum entropy principle in the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Origins of Genetic Coding: Self-Guided Molecular Self-Organisation.Entropy (Basel, Switzerland) · 2023Article
- Article
- Fitting the standard genetic code into its triplet table.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The influence of different types of translational inaccuracies on the genetic code structure.BMC bioinformatics · 2019Article
- The optimality of the standard genetic code assessed by an eight-objective evolutionary algorithm.BMC evolutionary biology · 2018Article
- Bijective codon transformations show genetic code symmetries centered on cytosine's coding properties.Theory in biosciences = Theorie in den Biowissenschaften · 2018Article
- Optimization of the standard genetic code according to three codon positions using an evolutionary algorithm.PloS one · 2018Article
- The genetic code. Rewritten, revised, repurposed.Artificial DNA, PNA & XNA · 2014Article
- Revisiting the physico-chemical hypothesis of code origin: an analysis based on code-sequence coevolution in a finite population.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?Journal of the Royal Society, Interface · 2013Article
- An alternative look at code evolution: using non-canonical codes to evaluate adaptive and historic models for the origin of the genetic code.Journal of molecular evolution · 2013Article
- CMCpy: Genetic Code-Message Coevolution Models in Python.Evolutionary bioinformatics online · 2013Article
- Unassigned codons, nonsense suppression, and anticodon modifications in the evolution of the genetic code.Journal of molecular evolution · 2011Article
- Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase.The Journal of biological chemistry · 2011Article
- Comparison of translation loads for standard and alternative genetic codes.BMC evolutionary biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The standard genetic code is the nearly universal system for the translation of genes into proteins. The code exhibits two salient structural characteristics: it possesses a distinct organization that makes it extremely robust to errors in replication and translation, and it is highly redundant. The origin of these properties has intrigued researchers since the code was first discovered. One suggestion, which is the subject of this review, is that the code's organization is the outcome of the coevolution of genes and genetic codes. In 1968, Francis Crick explored the possible implications of coevolution at different stages of code evolution. Although he argues that coevolution was likely to influence the evolution of the code, he concludes that it falls short of explaining the organization of the code we see today. The recent application of mathematical modeling to study the effects of errors on the course of coevolution, suggests a different conclusion. It shows that coevolution readily generates genetic codes that are highly redundant and similar in their error-correcting organization to the standard code. We review this recent work and suggest that further affirmation of the role of coevolution can be attained by investigating the extent to which the outcome of coevolution is robust to other influences that were present during the evolution of the code.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.