ReviewPediatric nephrology (Berlin, Germany)2006
Cystatin C, kidney function and cardiovascular disease.
Review in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Associations of proanthocyanidin intake with renal function and clinical outcomes in elderly women.PloS one · 2013Trial
- Gold Standard GFR measurement and GFR estimation in pediatric oncology - indications and limitations.Pediatric nephrology (Berlin, Germany) · 2026Review
- Enhanced cardiovascular disease risk prediction using integrated machine learning models: a study from the UK Biobank cohort.Open heart · 2026Article
- Prognostic value of serum cystatin C and its changes in patients with ST-segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
- Article
- The Diverse Efficacy of Food-Derived Proanthocyanidins for Middle-Aged and Elderly Women.Nutrients · 2020Review
- The association between creatinine versus cystatin C-based eGFR and cardiovascular risk in children with chronic kidney disease using a modified PDAY risk score.Pediatric nephrology (Berlin, Germany) · 2017Article
- Childhood Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C: Importance of Body Composition.American journal of nephrology · 2017Article
- Methods of assessing renal function.Pediatric nephrology (Berlin, Germany) · 2014Review
- Cystatin C in children on chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2013Article
- Cystatin C: a strong marker for lower limb ischemia in Chinese type 2 diabetic patients?PloS one · 2013Article
- The association between renal function biomarkers and subclinical cardiovascular measures in African Caribbean families.Ethnicity & disease · 2013Article
- Cystatin C is associated with inflammation but not atherosclerosis in systemic lupus erythematosus.Lupus · 2012Article
- Which creatinine and cystatin C equations can be reliably used in children?Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- The relationship of cystatin C, creatinine, estimated GFR, and cardiovascular events.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2010Article
- Lack of Association between Serum Cystatin C Levels and Coronary Artery Disease in Diabetic Patients.Korean diabetes journal · 2010Article
- Measuring glomerular filtration rate in children; can cystatin C replace established methods? A review.Pediatric nephrology (Berlin, Germany) · 2009Review
- Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.Circulation · 2009Article
- Correlation between cystatin C- and renal scan-determined glomerular filtration rate in children with spina bifida.Pediatric nephrology (Berlin, Germany) · 2008Article
- Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth.Pediatric nephrology (Berlin, Germany) · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystatin C, an endogenous low-molecular-weight marker of glomerular filtration rate, has recently been shown to be associated with future cardiovascular disease in healthy elderly populations and patients with documented atherosclerosis in a dose-dependent manner that possibly reflects a very early stage of chronic renal dysfunction. At the same time, local cystatin C deficiency has been demonstrated in atherosclerotic and aneurismal lesions, suggesting a protective role of cystatin C in the vessel wall, possibly in concert with TGF-beta1. Although cystatin C is not an acute phase reactant, large epidemiological studies have documented a highly significant association between serum cystatin C and mildly increased C-reactive protein (CRP) levels, the hallmark of the chronic inflammatory state associated with atherosclerosis and chronic renal failure. Since cystatin C is produced by all nucleated cells, it is unlikely that local variations in cystatin C synthesis in diseased arteries--rather than global cystatin C production and renal elimination--should determine its serum concentration. Consequently, the present review proposes microinflammation as the unifying concept for both lines of evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.