ArticleInternational journal of colorectal disease2007
Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03000101 (New Insight and Knowledge on Anti-inflammatory Effectiveness of Dietary Phenolics), which is not on this map. Cited by 69 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
New Insight and Knowledge on Anti-inflammatory Effectiveness of Dietary Phenolics (NIKE)
Who cites it
69 citing papers in PubMed, 6 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis.BMC gastroenterology · 2022Pooled it
- C-Reactive Protein, Fecal Calprotectin, and Stool Lactoferrin for Detection of Endoscopic Activity in Symptomatic Inflammatory Bowel Disease Patients: A Systematic Review and Meta-Analysis.The American journal of gastroenterology · 2015Pooled it
- A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS.The American journal of gastroenterology · 2015Pooled it
- Diagnostic accuracy of fecal lactoferrin for inflammatory bowel disease: a meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Fecal lactoferrin in discriminating inflammatory bowel disease from irritable bowel syndrome: a diagnostic meta-analysis.BMC gastroenterology · 2014Pooled it
- Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis.BMJ (Clinical research ed.) · 2010Pooled it
- Association of Biomarker Cutoffs and Endoscopic Outcomes in Crohn's Disease: A Post Hoc Analysis From the CALM Study.Inflammatory bowel diseases · 2020Trial
- Early change in serum leucine-rich α-2-glycoprotein predicts clinical and endoscopic response in ulcerative colitis.Intestinal research · 2024Article
- The Impact of Phenotype of Inflammatory Bowel Diseases, Inflammation Activity and Therapy on Mucosal Mature Cd83Journal of clinical medicine · 2024Article
- Review
- Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review.Journal of clinical medicine · 2021Article
- Diagnostic accuracy of fecal calprotectin in predicting significant gastrointestinal diseases.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.Frontiers in nutrition · 2021Review
- Correlation between Fecal Calprotectin Levels in Meconium and Vitamin D Levels in Cord Blood: Association with Intestinal Distress.Journal of clinical medicine · 2020Article
- Assessing Severity of Disease in Patients with Ulcerative Colitis.Gastroenterology clinics of North America · 2020Review
- Calprotectin in inflammatory bowel disease.Clinica chimica acta; international journal of clinical chemistry · 2020Review
- Relationship between faecal metronidazole and lactoferrin concentrations to clinical response of patients with Clostridioides difficile.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- The Role of Fecal Calprotectin in Patients with Systemic Sclerosis and Small Intestinal Bacterial Overgrowth (SIBO).Diagnostics (Basel, Switzerland) · 2020Article
- The level of faecal calprotectin as a noninvasive biomarker of mucosal healing in children with ulcerative colitis.Przeglad gastroenterologiczny · 2020Article
- Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity.Digestive diseases and sciences · 2019Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsCalprotectin and lactoferrin are specific neutrophil-derived proteins, which can be measured in the feces because they are released by cells in inflammatory conditions. We evaluated the efficacy of calprotectin and lactoferrin in detecting organic disease as assessed by colonoscopy.
methodsThe study comprised 144 patients undergoing colonoscopy for lower gastrointestinal symptoms (abdominal pain, altered bowel habits, and bloody stools) (67), or inflammatory bowel disease activity, or surveillance for dysplasia (77). A single stool sample was assayed for calprotectin and lactoferrin. The proportion of patients correctly diagnosed with each test and the relationship with endoscopic and histological findings were measured.
resultsFecal excretion of calprotectin significantly correlated with the finding of colonic inflammation at endoscopy, both in ulcerative colitis and in Crohn's disease (p<0,001 and p<0,008, respectively), while lactoferrin excretion significantly correlated with histological inflammation (p=0.001 and p=0.009 respectively). Recommended cut-off values need to be adjusted in the inflammatory bowel disease group. Overall sensitivity, specificity, positive predictive value, and diagnostic efficacy were 78, 83, 86, and 80% for calprotectin and 80, 85, 87, and 81% for lactoferrin, respectively.
conclusionsFecal calprotectin and lactoferrin appear to be equally recommendable as inflammatory disease markers in patients with lower gastrointestinal symptoms. Both tests are needed to accurately discriminate activity in inflammatory bowel disease patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.