ArticleDigestive diseases and sciences2006
Histamine mediates the stimulatory action of ghrelin on acid secretion in rat stomach.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Protective and Healing Effects of Ghrelin and Risk of Cancer in the Digestive System.International journal of molecular sciences · 2021Review
- Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa.Cell and tissue research · 2019Article
- Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus.Cell and tissue research · 2019Article
- Translating Developmental Principles to Generate Human Gastric Organoids.Cellular and molecular gastroenterology and hepatology · 2018Review
- Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus.PloS one · 2015Article
- Structure and physiological actions of ghrelin.Scientifica · 2013Review
- The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Comparison of the actions of acylated and desacylated ghrelin on acid secretion in the rat stomach.Journal of gastroenterology · 2010Article
- Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis.Journal of gastroenterology · 2009Article
- Hormonal regulation of gastric acid secretion.Current gastroenterology reports · 2008Review
- Ghrelin and gastric acid secretion.World journal of gastroenterology · 2008Review
- Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract.World journal of gastroenterology · 2008Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ghrelin, a novel growth hormone-releasing peptide, is present in the rat and human stomach and is known to stimulate acid secretion and stomach motility. However, the mechanism of action of ghrelin is not fully understood. In the present study, we attempted to elucidate the role of histamine in ghrelin-induced acid secretion in rat stomach. Intravenous administration of ghrelin at 0.8 to 20 microg/kg dose dependently increased gastric acid secretion, as measured by the gastric lumen perfusion method. The maximum response was almost equal to that of gastrin (20 microg/kg). These actions were abolished by bilateral subdiaphragmatic vagotomy. Famotidine (0.33 mg/kg) also completely inhibited the effects of ghrelin. Furthermore, ghrelin increased histidine decarboxylase (HDC) messenger RNA (mRNA) levels, as measured by real-time reverse transcription-polymerase chain reaction using LightCycler. The action of ghrelin on HDC mRNA was abolished by vagotomy. Ghrelin did not affect histamine release from isolated vascularly perfused rat stomach. Taken together, these results suggest that ghrelin stimulates gastric acid secretion via a mechanism involving activation of vagal efferent nerve and histamine release from gastric enterochromaffin-like cells.
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Registered trials
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