ArticleDigestive diseases and sciences2006
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Oxy-inflammation in hyperbaric oxygen therapy applications.European journal of translational myology · 2025Article
- Evaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapy.Clinics (Sao Paulo, Brazil) · 2023Article
- The effect of hyperbaric oxygen therapy in the inflammatory response in a mouse model of endometriosis: An experimental study.International journal of reproductive biomedicine · 2022Article
- The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review.Advances in experimental medicine and biology · 2021Review
- [Effects of combined natural hirudin and hyperbaric oxygen therapy on survival of transplanted random-pattern skin flap in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- The acute antinociceptive effect of hyperbaric oxygen is not accompanied by an increase in markers of oxidative stress.Life sciences · 2014Article
- Involvement of spinal cord opioid mechanisms in the acute antinociceptive effect of hyperbaric oxygen in mice.Brain research · 2013Article
- Anti-granuloma activity of Coriandrum sativum in experimental models.Journal of Ayurveda and integrative medicine · 2013Article
- Hyperbaric oxygen treatment in autism spectrum disorders.Medical gas research · 2012Article
- Investigation into the anti-inflammatory and antigranuloma activity of Colchicum luteum Baker in experimental models.Inflammation · 2012Article
- Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis.Medical gas research · 2012Article
- 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.Digestive diseases and sciences · 2008Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of hyperbaric oxygenation (HBO2) was investigated in a rat model of indomethacin-induced enteropathy. Enteropathy was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) 24 hr apart. Six groups of rats (n=8) were treated with and without HBO2 (100% oxygen at 2.3 atm absolute) for 1 hr once or twice a day for 2 or 5 days. Disease activity index (DAI) and total ulcer length were measured. Other rats were randomized into two groups (n=16) with and without HBO2 (1 hr once a day) and four rats were killed in each group at 12, 24, 48, and 72 hr after the final injection of indomethacin. Serum and intestinal mucosal TNF-alpha, IL-1beta, myeloperoxidase (MPO), and iNOS expression was measured. HBO2 treatment significantly attenuated indomethacin -induced intestinal ulceration and improved DAI. Indomethacin increased MPO activity and iNOS expression, and these were reduced by HBO2 treatment, with a concomitant reduction in TNF-alpha and IL-1beta. Our data suggest that HBO2 treatment has a beneficial effect on indomethacin-induced enteropathy and this effect is possibly mediated by decreased production of TNF-alpha and IL-1beta.
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