Trial reportJournal of perinatology : official journal of the California Perinatal Association2006
Nasal continuous positive airway pressure from high flow cannula versus Infant Flow for Preterm infants.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure for Non-Invasive Respiratory Support in Neonates
Adaptive Dynamic Inspiratory Nasal Apparatus (ADINA): Comparison to High Flow Nasal Cannula (HFNC)
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Postextubation use of non-invasive respiratory support in preterm infants: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Peri-extubation settings in preterm neonates: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Continuous positive airway pressure (CPAP) for apnoea of prematurity.The Cochrane database of systematic reviews · 2023Pooled it
- High flow nasal cannula for respiratory support in preterm infants.The Cochrane database of systematic reviews · 2016Pooled it
- High-flow nasal cannula therapy for respiratory support in children.The Cochrane database of systematic reviews · 2014Pooled it
- Infant flow biphasic nasal continuous positive airway pressure (BP- NCPAP) vs. infant flow NCPAP for the facilitation of extubation in infants' ≤ 1,250 grams: a randomized controlled trial.BMC pediatrics · 2012Trial
- High-flow nasal cannula use for respiratory support in children for indications other than acute bronchiolitis.The Cochrane database of systematic reviews · 2026Article
- Noninvasive Positive Airway Pressure Management for Post-extubation Support in Preterm Infants: Observational Cohort Study with Overlap Weighting Analysis.Annals of clinical epidemiology · 2024Article
- Nasal high flow therapy for primary respiratory support in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Bubble devices versus other pressure sources for nasal continuous positive airway pressure in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Review
- Nasal high flow treatment in preterm infants.Maternal health, neonatology and perinatology · 2017Review
- High flow nasal cannula in extubated patients: is it advantageous over conventional oxygen therapy?Journal of thoracic disease · 2016Article
- High Flow Nasal Cannulae versus Nasal Continuous Positive Airway Pressure in Neonates with Respiratory Distress Syndrome Managed with INSURE Method: A Randomized Clinical Trial.Iranian journal of medical sciences · 2016Article
- Respiratory support with heated humidified high flow nasal cannula in preterm infants.Korean journal of pediatrics · 2016Review
- High Flow Nasal Cannula Use Is Associated with Increased Morbidity and Length of Hospitalization in Extremely Low Birth Weight Infants.The Journal of pediatrics · 2016Article
- High-flow Nasal Cannulae in Very Preterm Infants after Extubation.Journal of clinical neonatology · 2014Article
- Work of breathing indices in infants with respiratory insufficiency receiving high-flow nasal cannula and nasal continuous positive airway pressure.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- High-flow nasal cannula oxygen for bronchiolitis in a pediatric ward: a pilot study.European journal of pediatrics · 2013Observational
- Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature.Intensive care medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the feasibility of continuous positive airway pressure (CPAP) support generated by high flow nasal cannula with conventional CPAP for prevention of reintubation among preterm infants with a birth weight of <or=1,250 g. STUDY
designPreterm infants were randomized to CPAP generated via high flow cannula or the Infant Flow Nasal CPAP System (VIASYS, Conshohocken, PA, USA) at extubation. Primary outcome was incidence of reintubation within 7 days. Secondary outcomes included change in oxygen use and frequency of apnea and bradycardias postextubation.
resultsForty neonates were randomized. Twelve of 20 infants randomized to high flow cannula CPAP were reintubated compared to three of 20 using Infant Flow (P=0.003). The high flow cannula group had increased oxygen use and more apneas and bradycardias postextubation.
conclusionsCPAP delivered by high flow nasal cannula failed to maintain extubation status among preterm infants <or=1,250 g as effectively as Infant Flow CPAP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.