ArticleJournal of acquired immune deficiency syndromes (1999)2006
In vivo effects of HIV-1 exposure in the presence and absence of single-dose nevirapine on cellular plasma activation markers of infants born to HIV-1-seropositive mothers.
Article in Journal of acquired immune deficiency syndromes (1999), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Low maternal viral loads and reduced granulocyte-macrophage colony-stimulating factor levels characterize exposed, uninfected infants who develop protective human immunodeficiency virus type 1-specific responses.Clinical and vaccine immunology : CVI · 2007Trial
- Reduced B cell frequencies in cord blood of HIV-exposed uninfected infants: an immunological and transcriptomic analysis.Frontiers in immunology · 2024Article
- Growth Trajectories of HIV Exposed and HIV Unexposed Infants. A Prospective Study in Gweru, Zimbabwe.Global pediatric health · 2021Article
- The Effect of Human Immunodeficiency Virus and Cytomegalovirus Infection on Infant Responses to Vaccines: A Review.Frontiers in immunology · 2018Review
- Growth pattern in Ethiopian infants - the impact of exposure to maternal HIV infection in relation to socio-economic factors.Global health action · 2017Article
- Breastfeeding Behaviors and the Innate Immune System of Human Milk: Working Together to Protect Infants against Inflammation, HIV-1, and Other Infections.Frontiers in immunology · 2017Review
- HIV-Exposed Uninfected Infants in Zimbabwe: Insights into Health Outcomes in the Pre-Antiretroviral Therapy Era.Frontiers in immunology · 2016Article
- Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns.Frontiers in immunology · 2016Review
- Impact of elevated maternal HIV viral load at delivery on T-cell populations in HIV exposed uninfected infants in Mozambique.BMC infectious diseases · 2015Article
- The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination.AIDS (London, England) · 2015Article
- In-utero infection with HIV-1 associated with suppressed lymphoproliferative responses at birth.Clinical and experimental immunology · 2014Article
- Altered innate immune development in HIV-exposed uninfected infants.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- HIV-exposed uninfected children: a growing population with a vulnerable immune system?Clinical and experimental immunology · 2014Review
- Naturally-occurring genetic variants in human DC-SIGN increase HIV-1 capture, cell-transfer and risk of mother-to-child transmission.PloS one · 2012Article
- Article
- Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.The open AIDS journal · 2010Article
- Article
- Single-dose nevirapine exposure affects T cell response and cytokine levels in HIV type 1-infected women.AIDS research and human retroviruses · 2009Article
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.Pediatric research · 2009Review
- Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.Journal of acquired immune deficiency syndromes (1999) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Short-course antiretroviral drug regimens reduce the risk of mother-to-child transmission of HIV-1, but mechanisms affording protection of such interventions remain poorly defined. Because T-cell activation is an important factor in productive HIV-1 infection, we tested the hypothesis that single-dose nevirapine (NVP) reduces immune activation, which in turn reduces the likelihood of transmission. We compared concentrations of cord and maternal blood plasma immune activation markers, neopterin, beta2-microglobulin, and soluble l-selectin, in 2 groups of HIV-1-exposed newborns whose mothers either received NVP at the onset of labor or who only received NVP as postexposure prophylaxis within 72 hours of birth and among HIV-unexposed controls. In utero exposure of the infant to HIV-1, regardless of NVP exposure, led to demonstrable increases in immune activation markers, this being most notable in the presence of preexisting infection. Contrary to what was hypothesized, immune activation was increased by prebirth exposure to single-dose NVP, with this effect being enhanced in infants already infected at birth. Our data suggest that reductions in immune activation do not explain transmission prevention effects of single-dose NVP. Our data also suggest a biological explanation for why HIV-1-infected infants exposed perinatally to antiretroviral drugs might experience hastened disease progression, namely, in some HIV-1-infected individuals, NVP may synergize with HIV-1 to enhance an environment that favors increased HIV-1 replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.