ArticleThe American journal of tropical medicine and hygiene2006
Competition for red blood cells can enhance Plasmodium vivax parasitemia in mixed-species malaria infections.
Article in The American journal of tropical medicine and hygiene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Plasmodium vivax and Plasmodium falciparum mixed infections in human and mosquito hosts: The impact of multi-species infection on parasite densities and transmission to mosquitoes.PLoS neglected tropical diseases · 2026Article
- Article
- Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use.Current research in parasitology & vector-borne diseases · 2025Review
- Modeling and investigating malaria P. Falciparum and P. Vivax infections: Application to Djibouti data.Infectious Disease Modelling · 2024Article
- Non-random distribution of Plasmodium Species infections and associated clinical features in children in the lake Victoria region, Kenya, 2012-2018.Tropical medicine and health · 2024Article
- Co-infection with Leucocytozoon and Other Haemosporidian Parasites Increases with Latitude and Altitude in New World Bird Communities.Microbial ecology · 2023Article
- Experimental Study on Primary Bird Co-Infection with TwoAnimals : an open access journal from MDPI · 2022Article
- Reciprocal positive effects on parasitemia between coinfecting haemosporidian parasites in house sparrows.BMC ecology and evolution · 2022Article
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Analysis of erythrocyte dynamics in Rhesus macaque monkeys during infection with Plasmodium cynomolgi.Malaria journal · 2018Article
- Avian malaria co-infections confound infectivity and vector competence assays of Plasmodium homopolare.Parasitology research · 2018Article
- Facilitation through altered resource availability in a mixed-species rodent malaria infection.Ecology letters · 2016Article
- The niche reduction approach: an opportunity for optimal control of infectious diseases in low-income countries?BMC public health · 2014Review
- War and peace: social interactions in infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans.Nature communications · 2013Article
- Foetal haemoglobin and the dynamics of paediatric malaria.Malaria journal · 2012Article
- Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.Journal of the Royal Society, Interface · 2012Article
- Competition and the evolution of reproductive restraint in malaria parasites.The American naturalist · 2011Article
- Population dynamics of a pathogen: the conundrum of vivax malaria.Biophysical reviews · 2010Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We assess the consequences of competition for red blood cells (RBCs) in co-infections with the two major agents of human malaria, Plasmodium vivax and Plasmodium falciparum, using differential equations to model the population dynamics of RBCs and parasites. P. vivax parasitizes only the youngest RBCs, but this can reduce the broader RBC population susceptible to P. falciparum. We found that competition for RBCs typically causes one species to suppress the other, depending on their relative reproduction rates and timing of inoculation. However, if the species' reproduction rates are nearly equal, transient increases in RBC production stimulated by the presence of P. falciparum may boost P. vivax parasitemia above its single-species infection level. Conversely, P. falciparum parasitemia is rarely enhanced above its single-species level. Furthermore, transients in RBC production can induce coupled oscillations in the parasitemia of both species. These results are remarkably robust to changes in model parameters.
Indexed as
Identifiers
16837717PMC2483695W2110793373What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.