ArticleThe American journal of tropical medicine and hygiene2006
Immune correlates of acute Mycobacterium tuberculosis infection in household contacts in Kampala, Uganda.
Article in The American journal of tropical medicine and hygiene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada.BMC infectious diseases · 2020Article
- Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil.BMC infectious diseases · 2017Article
- Identification of Host Proteins Predictive of Early Stage Mycobacterium tuberculosis Infection.EBioMedicine · 2017Article
- Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.PloS one · 2017Article
- Cough Aerosol Cultures of Mycobacterium tuberculosis: Insights on TST / IGRA Discordance and Transmission Dynamics.PloS one · 2015Article
- Tuberculosis case finding in first-degree relative contacts not living with index tuberculosis cases in Kampala, Uganda.Clinical epidemiology · 2015Article
- Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda.BMC infectious diseases · 2014Article
- Impact of co-infections and BCG immunisation on immune responses among household contacts of tuberculosis patients in a Ugandan cohort.PloS one · 2014Article
- Article
- Relapse more common than reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2013Article
- The household contact study design for genetic epidemiological studies of infectious diseases.Frontiers in genetics · 2013Article
- Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda.The American journal of tropical medicine and hygiene · 2012Article
- Missed opportunity for tuberculosis case detection in household contacts in a high burden setting.The Pan African medical journal · 2012Article
- Comparison of interferon gamma-inducible protein-10 and interferon gamma-based QuantiFERON TB Gold assays with tuberculin skin test in HIV-infected subjects.Diagnostic microbiology and infectious disease · 2011Article
- Determination of circulating Mycobacterium tuberculosis strains and transmission patterns among pulmonary TB patients in Kawempe municipality, Uganda, using MIRU-VNTR.BMC research notes · 2011Article
- Article
- Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganda.BMC infectious diseases · 2010Article
- Significant variation in presentation of pulmonary tuberculosis across a high resolution of CD4 strata.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2010Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
Abstract
To determine immunologic and epidemiologic correlates of acute Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis cases, we performed a prospective, community-based cohort study of index cases and their household contacts in Kampala, Uganda. Contacts were evaluated for tuberculin skin test (TST) conversion over two years. Interferon-gamma expression was measured using a whole blood assay after stimulating with M. tuberculosis culture-filtrate. In 222 contacts with a TST less than 5 mm at baseline, the one-year rate of TST conversion was 27%. The TST conversion was associated with the infectiousness of the index case and proximity of contact. Interferon-gamma levels at baseline were greater among TST converters compared with those who did not convert. The risk of TST conversion increased four-fold as the baseline interferon-gamma increased 10-fold, but only in contacts with BCG vaccination. In household contacts of tuberculosis, interferon-gamma responses to non-specific mycobacterial antigens may be used to make an early diagnosis of tuberculosis infection, especially in resource-limited settings where bacille Calmette-Guérin vaccination is commonly used.
Indexed as
Identifiers
16837709PMC2869089W2099998016What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.