ArticleMolecular biology of the cell2006
Capacity of the Golgi apparatus for cargo transport prior to complete assembly.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Unconventional Protein Transport Across the Golgi Ribbon.Sub-cellular biochemistry · 2026Review
- Sec71 separates Golgi stacks inJournal of cell science · 2020Article
- Article
- Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin- chitosan nanoparticles loading paclitaxel- cholesterol complex.International journal of nanomedicine · 2019Article
- COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.Nucleic acids research · 2018Article
- Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures.Platelets · 2017Article
- Cell cycle regulation of Golgi membrane dynamics.Trends in cell biology · 2013Review
- Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization.Scientific reports · 2013Article
- Electron tomography reveals Rab6 is essential to the trafficking of trans-Golgi clathrin and COPI-coated vesicles and the maintenance of Golgi cisternal number.Traffic (Copenhagen, Denmark) · 2012Article
- Live-cell assays to identify regulators of ER-to-Golgi trafficking.Traffic (Copenhagen, Denmark) · 2012Article
- Clathrin is required for postmitotic Golgi reassembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Sequential depletion and acquisition of proteins during Golgi stack disassembly and reformation.Traffic (Copenhagen, Denmark) · 2010Article
- Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Membrane traffic within the Golgi apparatus.Annual review of cell and developmental biology · 2009Review
- Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.Molecular biology of the cell · 2008Article
- Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.Molecular biology of the cell · 2007Article
- Endosomal recycling controls plasma membrane area during mitosis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In yeast, particular emphasis has been given to endoplasmic reticulum (ER)-derived, cisternal maturation models of Golgi assembly while in mammalian cells more emphasis has been given to golgins as a potentially stable assembly framework. In the case of de novo Golgi formation from the ER after brefeldin A/H89 washout in HeLa cells, we found that scattered, golgin-enriched, structures formed early and contained golgins including giantin, ranging across the entire cis to trans spectrum of the Golgi apparatus. These structures were incompetent in VSV-G cargo transport. Second, we compared Golgi competence in cargo transport to the kinetics of addition of various glycosyltransferases and glycosidases into nascent, golgin-enriched structures after drug washout. Enzyme accumulation was sequential with trans and then medial glycosyltransferases/glycosidases found in the scattered, nascent Golgi. Involvement in cargo transport preceded full accumulation of enzymes or GPP130 into nascent Golgi. Third, during mitosis, we found that the formation of a golgin-positive acceptor compartment in early telophase preceded the accumulation of a Golgi glycosyltransferase in nascent Golgi structures. We conclude that during mammalian Golgi assembly components fit into a dynamic, first-formed, multigolgin-enriched framework that is initially cargo transport incompetent. Resumption of cargo transport precedes full Golgi assembly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.