Trial reportThe British journal of ophthalmology2006
Randomised controlled study of conjunctival autograft versus amniotic membrane graft in pterygium excision.
Trial report in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Amniotic membrane transplantation and conjunctival autograft combined with mitomycin C for the management of primary pterygium: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Conjunctival Autograft Versus Amniotic Membrane Transplantation for Treatment of Pterygium: Findings From a Cochrane Systematic Review.American journal of ophthalmology · 2017Pooled it
- Conjunctival autograft for pterygium.The Cochrane database of systematic reviews · 2016Pooled it
- Comparison of conjunctival autograft transplantation and amniotic membrane transplantation for pterygium: a meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Pooled it
- A randomized controlled trial comparing limbal-conjunctival autograft with conjunctival autograft in recurrent pterygium surgery with intraoperative application of 0.02% mitomycin C.International ophthalmology · 2026Trial
- Fifteen-year results of a randomized controlled trial comparing 0.02% mitomycin C, limbal conjunctival autograft, and combined mitomycin C with limbal conjunctival autograft in recurrent pterygium surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Trial
- Efficacy of preoperative injection versus intraoperative application of mitomycin in recurrent pterygium surgery.Indian journal of ophthalmology · 2012Trial
- Sutureless amniotic membrane transplantation combined with narrow-strip conjunctival autograft for pterygium.International ophthalmology · 2011Trial
- Article
- A Retrospective Review of Glueless, Sutureless Pterygium Excision Using Biovance Triple-Layer Decellularized Amniotic Basement Membrane Tissue.Ophthalmology and therapy · 2026Article
- Utilization Patterns and Costs of Ocular Amniotic Membrane Grafts in the Medicare Population.Ophthalmology · 2026Article
- Risk factors for pterygium recurrence based on a retrospective study of 196 patients.Scientific reports · 2025Article
- Ocular surface squamous neoplasia in a patient following oral steroids for contralateral necrotising scleritis.BMJ case reports · 2022Article
- Safety and efficacy of pterygium extended removal followed by extended conjunctival transplant for recurrent pterygia.International ophthalmology · 2022Article
- Characteristics and recurrence of pterygium in Saudi Arabia: a single center study with a long follow-up.BMC ophthalmology · 2021Article
- Efficacy of second donor conjunctival graft from the same site for pterygium - A retrospective analysis.Indian journal of ophthalmology · 2021Article
- Evaluation of Conjunctival Autografting Augmented with Mitomycin C ApplicationJournal of ophthalmology · 2021Article
- Recurrence of Pterygium after Pterygium Excision with Stem Cell Graft and Amniotic Membrane Graft: A Comparison.Cureus · 2020Article
- Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium.BMC ophthalmology · 2018Article
- Clinical outcome of combined conjunctival autograft transplantation and amniotic membrane transplantation in pterygium surgery.International journal of ophthalmology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine whether amniotic membrane can be used as an alternative to conjunctival autograft after pterygium excision.
methods287 eyes with either primary or recurrent pterygium were included in this study. All eyes were randomised to undergo conjunctival autograft or amniotic membrane transplantation after pterygium excision by a single surgeon. 106 eyes in primary pterygium and 14 eyes in the recurrent group were treated with conjunctival autograft, and 148 eyes in primary pterygium and 19 eyes in the recurrent group were treated with amniotic membrane transplantation. Patients were followed up at 6 weeks and 6 months after operation. The main outcome measurement was recurrence rate after surgery.
resultsIn the conjunctival group, the recurrence rate was 12.3%, 21.4% and 13.1% for primary, recurrent and all pterygia, respectively. In the amniotic membrane group, the recurrence rate was 25.0%, 52.6% and 28.1% for primary, recurrent and all pterygia, respectively. The recurrence rate for all pterygia in the amniotic membrane group was significantly higher than that in the conjunctival group (p = 0.003).
conclusionsAmniotic membrane graft had a higher recurrence rate than conjunctival autograft. However, it is an alternative choice, especially for advanced cases with bilateral heads or patients who might need glaucoma surgery later.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.