Evidence map›Paper›PMID 16836741›Full record

ArticleBMC bioinformatics2006

HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics.

Roel G W Verhaak, Mathijs A Sanders, Maarten A Bijl, Ruud Delwel, Sebastiaan Horsman, Michael J Moorhouse, Peter J van der Spek, Bob Löwenberg, Peter J M Valk

Abstract read
In one paragraph

Article in BMC bioinformatics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  7. The Original Form of CFrontiers in plant science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roel G W VerhaakDepartment of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. r.verhaak@erasmusmc.nl
Mathijs A Sanders
Maarten A Bijl
Ruud Delwel
Sebastiaan Horsman
Michael J Moorhouse
Peter J van der Spek
Bob Löwenberg
Peter J M Valk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate interpretation of data obtained by unsupervised analysis of large scale expression profiling studies is currently frequently performed by visually combining sample-gene heatmaps and sample characteristics. This method is not optimal for comparing individual samples or groups of samples. Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata.

resultsWe have developed a tool called the HeatMapper that provides such visualizations in a dynamic and flexible manner and is available from http://www.erasmusmc.nl/hematologie/heatmapper/.

conclusionThe HeatMapper allows an accessible and comprehensive visualization of the results of gene expression profiling and cluster analysis.

Indexed as

SoftwareAntigens, CD34Cluster AnalysisData Interpretation, StatisticalGene Expression ProfilingGenotypeHumansKaryotypingLeukemia, MyeloidNuclear ProteinsNucleophosminOligonucleotide Array Sequence AnalysisPhenotypeAntigens, CD34Nuclear ProteinsNucleophosmin

Identifiers

PMID16836741
PMCPMC1574351

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.