ArticleHuman genetics1991
Multicolor fluorescence in situ hybridization and pulsed field electrophoresis dissect CMT1B gene region.
Article in Human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- The genetic contribution to the phenotype.Human genetics · 1995Review
- Tomaculous neuropathy in chromosome 1 Charcot-Marie-Tooth syndrome.Acta neuropathologica · 1994Article
- Myelin protein zero gene mutated in Charcot-Marie-tooth type 1B patients.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Multicolor fluorescence in situ hybridization and pulsed field electrophoresis dissect CMT1B gene region.Human genetics · 1991Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We have used multicolor fluorescence in situ hybridization of banded chromosomes to orient Fc gamma RII and clone 1054 on a single early metaphase chromosome band (1q22) representing about 2% of the physical map of chromosome 1 in the Charcot-Marie-Tooth (CMT1B) gene region. These two cloned fragments are on the same partially digested 900-kb MluI fragment detected by pulsed field gel electrophoresis. When applied to data from an earlier study, multicolor in situ hybridization results further refined the CMT1B genetic location from an 18 cM interval to a 6 cM interval and the physical map from 15% of chromosome 1 to 3% of chromosome 1. Occasionally the three Fc gamma RII immunoglobulin receptor genes within the 200-kb region are resolved in individual metaphase chromatids.
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