ArticleHistochemistry and cell biology2006
Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Restore the brake on tumor progression.Biochemical pharmacology · 2017Review
- Evidence for a common progenitor of epithelial and mesenchymal components of the liver.Cell death and differentiation · 2013Article
- Hepatic stem cell niches.The Journal of clinical investigation · 2013Review
- The role of stem cells in liver repair and fibrosis.The international journal of biochemistry & cell biology · 2011Review
- Hedgehog signaling in the liver.Journal of hepatology · 2011Review
- Disparate cellular basis of improved liver repair in beta-catenin-overexpressing mice after long-term exposure to 3,5-diethoxycarbonyl-1,4-dihydrocollidine.The American journal of pathology · 2010Article
- Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium.In vitro cellular & developmental biology. Animal · 2010Article
- Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas.Virchows Archiv : an international journal of pathology · 2009Article
- Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers.Stem cells (Dayton, Ohio) · 2008Article
- Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans.Gastroenterology · 2008Article
- Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.Physiological reviews · 2008Review
- Recent progress on tissue-resident adult stem cell biology and their therapeutic implications.Stem cell reviews · 2008Review
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells.Journal of molecular histology · 2007Article
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
- Hepatocellular carcinoma may display elevated nestin expression in endothelial cells: experimental study.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oval cells constitute a heterogeneous population of proliferating progenitors found in rat livers following carcinogenic treatment (2-acetylaminofluorene and 70% hepatectomy). The aim of this study was to investigate the cellular pattern of various differentiation and cell type markers in this model of liver regeneration. Immunophenotypic characterisation revealed at least two subtypes emerging from the portal field. First, a population of oval cells formed duct-like structures and expressed bile duct (CD49f) as well as hepatocytic markers (alpha-foetoprotein, CD26). Second, a population of non-ductular oval cells was detected between and distally from the ductules expressing the neural marker nestin and the haematopoietic marker Thy1. Following oval cell isolation, a subset of the nestin-positive cells was shown to co-express hepatocytic and epithelial markers (albumin, CD26, pancytokeratin) and could be clearly distinguished from anti-desmin reactive hepatic stellate cells. The gene expression profiles (RT-PCR) of isolated oval cells and oval cell liver tissue were found to be similar to foetal liver (ED14). The present results suggest that the two oval cell populations are organised in a zonal hierarchy with a marker gradient from the inner (displaying hepatocytic and biliary markers) to the outer zone (showing hepatocytic and extrahepatic progenitor markers) of the proliferating progeny clusters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.