ArticleThe Journal of cell biology1991
A sialoglycoprotein complex linked to the microvillus cytoskeleton acts as a receptor for pilus (AF/R1) mediated adhesion of enteropathogenic Escherichia coli (RDEC-1) in rabbit small intestine.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection.Clinical and vaccine immunology : CVI · 2007Trial
- Protection against hemorrhagic colitis in an animal model by oral immunization with isogeneic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin.Infection and immunity · 2005Article
- Escherichia coli strain RDEC-1 AF/R1 endogenous fimbrial glycoconjugate receptor molecules in rabbit small intestine.Infection and immunity · 2001Article
- Effects of orally administered epidermal growth factor on enteropathogenic Escherichia coli infection in rabbits.Infection and immunity · 1998Article
- Colonization factors of diarrheagenic E. coli and their intestinal receptors.Journal of industrial microbiology · 1995Review
- Effect of enteropathogenic Escherichia coli on adherent properties of Chinese hamster ovary cells.Infection and immunity · 1995Article
- Characterization of porcine intestinal receptors for the K88ac fimbrial adhesin of Escherichia coli as mucin-type sialoglycoproteins.Infection and immunity · 1994Article
- Adhesion and its role in the virulence of enteropathogenic Escherichia coli.Clinical microbiology reviews · 1994Review
- Expression of receptors for enterotoxigenic Escherichia coli during enterocytic differentiation of human polarized intestinal epithelial cells in culture.Infection and immunity · 1992Article
- Thin aggregative fimbriae from diarrheagenic Escherichia coli.Journal of bacteriology · 1992Article
- Initial adherence of EPEC, EHEC and VTEC to host cells.Veterinary researchReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Escherichia coli strain RDEC-1 is an enteroadherent, diarrheagenic pathogen in rabbits that utilizes AF/R1 pili for initial (stage 1) adherence, but the host receptors for this adhesion are unknown. Here we demonstrate that RDEC-1 binds, via AF/R1 pili, to a specific rabbit ileal microvillus membrane glycoprotein receptor complex of subunits 130 and 140 kD. The binding involves sialic acid present on oligosaccharide moieties of the glycoprotein receptor. Furthermore, the microvillus membrane glycoprotein receptor complex appears to be associated with cytoskeletal components via brush border myosin 1. This newly described link between AF/R1 receptor and cytoskeletal components suggests that, in addition to this function in mucosal adherence, the pili may facilitate subsequent (second stage) close effacing attachment of RDEC-1 to the host epithelium by influencing cytoskeletal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.