Evidence map›Paper›PMID 16832659›Full record

Trial reportPsychopharmacology2006

PET imaging of cortical 11C-nicotine binding correlates with the cognitive function of attention in Alzheimer's disease.

Ahmadul Kadir, Ove Almkvist, Anders Wall, Bengt Långström, Agneta Nordberg

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. (+)-[European journal of nuclear medicine and molecular imaging · 2021
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  12. CaCells · 2020
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  15. Dementia spectrum disorders: lessons learnt from decades with PET research.Journal of neural transmission (Vienna, Austria : 1996) · 2019
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  18. Development and optimization of a novel automated loop method for production of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmadul KadirDepartment of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum Floor-5, Stockholm, 141 86, Sweden.
Ove Almkvist
Anders Wall
Bengt Långström
Agneta Nordberg

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationalePatients suffering from Alzheimer's disease (AD) experience a marked reduction in cortical nicotinic acetylcholine receptors (nAChRs). In particular, selective loss of the alpha4beta2 nAChR subtype was observed in postmortem AD brain tissue. The alpha4 and alpha7 nAChR subunits were suggested to play an important role in cognitive function. Positron emission tomography (PET) has so far been used to visualize neuronal nAChRs in vivo by 11C-nicotine binding.

objectivesTo investigate the relationship between measures of cognitive function and in vivo 11C-nicotine binding in mild AD brain as assessed by PET. MATERIALS AND

methodsTwenty-seven patients with mild AD were recruited in this study. A dual tracer model with administration of 15O-water for regional cerebral blood flow and (S)(-)11C-nicotine was used to assess nicotine binding sites in the brain by PET. Cognitive function was assessed using neuropsychological tests of global cognition, episodic memory, attention, and visuospatial ability.

resultsMean cortical 11C-nicotine binding significantly correlated with the results of attention tests [Digit Symbol test (r = -0.44 and p = 0.02) and Trail Making Test A (TMT-A) (r = 0.42 and p = 0.03)]. No significant correlation was observed between 11C-nicotine binding and the results of tests of episodic memory or visuospatial ability. Regional analysis showed that 11C-nicotine binding in the frontal and parietal cortex, which are the main areas for attention, correlated significantly with the Digit Symbol test and TMT-A results.

conclusionCortical nicotinic receptors in vivo in mild AD patients are robustly associated with the cognitive function of attention.

Indexed as

AgedAlzheimer DiseaseAttentionBrainCarbon RadioisotopesCognitionFemaleHumansMaleMemoryNeuropsychological TestsNicotineNicotinic AgonistsPositron-Emission TomographyReceptors, NicotinicCarbon RadioisotopesNicotineNicotinic AgonistsReceptors, Nicotinic

Identifiers

PMID16832659

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.